PMID: 15253041Jul 16, 2004Paper

Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay

Archives of Environmental Contamination and Toxicology
T OkuboI Kano

Abstract

Estrogenic activities of 20 selected pesticides-which are used for agricultural production as insecticides, fungicides and herbicides-were examined by estrogen receptor (ER)-dependent MCF-7 cell proliferation assay. Among them, chlordecone, dicofol, methoxychlor, gamma-HCH, fenarimol, EPN, triadimefon, and triadimenol had estrogenic activities, all of which were suppressed by the addition of pure antiestrogen ICI 182,780. The first 5 compounds exhibited binding capacities to ERalpha. The antiestrogenic activity of a compound was examined by estimating its suppressive effect on cell proliferation induced by 30 pM 17beta-estradiol. Strongly suspected antiestrogens were captan and myclobutanil, both of which were found to have the capacity to bind to ERalpha and which might exert their activities by competing at the level of ERalpha. Antiestrogenic activities of nitrofen, fenitrothion, fenarimol and triadimefon were also suggested. Affinities of the compounds for ERalpha and/or androgen receptor (AR) were lower than those of synthetic estrogen (diethylstilbestrol) and testosterone (mibolerone), respectively. Fenitrothion had the highest affinity to AR. Chlordecone, dicofol, methoxychlor, nitrofen, fenarimol, myclobutanil and pyrid...Continue Reading

Citations

Feb 12, 2011·Environmental Health Perspectives·Frances OrtonAndreas Kortenkamp
Jul 22, 2011·International Journal of Environmental Research and Public Health·Wissem MnifBenoit Roig
Nov 28, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Shahid Afzal GillAhrar Khan
Oct 24, 2013·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Patricia L Bishop, Catherine E Willett
Jul 3, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M Landau-OssondoUNKNOWN ARTAC international research group on pesticides
Jun 16, 2015·Environment International·Ryoiti Kiyama, Yuko Wada-Kiyama
Feb 24, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Cédric BovetRenato Zenobi
Jul 10, 2007·The Science of the Total Environment·Corine J HoutmanHans J C Klamer
Feb 22, 2012·Congenital Anomalies·Hiroaki AoyamaShoji Teramoto
Aug 2, 2005·Chemico-biological Interactions·Xiomara C Kretschmer, William S Baldwin
Jun 20, 2006·International Journal of Hygiene and Environmental Health·Mari ManabeToshimasa Nishiyama
Jul 28, 2005·Marine Pollution Bulletin·Gilles Bocquené, Alain Franco
Nov 13, 2007·International Immunopharmacology·Fei WangEric S Sobel
Sep 21, 2007·Environment International·R McKinlayN Voulvoulis
May 13, 2015·Journal of Toxicology and Environmental Health. Part a·Viviane M PascottoCarla A S Franchi
Jul 23, 2013·Toxicology and Applied Pharmacology·Lisbeth Stigaard KjeldsenEva Cecilie Bonefeld-Jørgensen
Dec 30, 2016·Environmental Science and Pollution Research International·Elena LegrandJoëlle Forget-Leray
Mar 6, 2013·Asia-Pacific Journal of Public Health·Dilshad A KhanHizbullah Khan
Dec 16, 2004·The Journal of Reproduction and Development·Soon-Sun KimKui-Lea Park
Sep 24, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rosemary A SchuhGary Fiskum
Nov 27, 2009·Systems Biology in Reproductive Medicine·Amber K GoetzDavid J Dix
Dec 19, 2013·Human & Experimental Toxicology·Pallav Sengupta, Rajdeb Banerjee
Sep 25, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mahboubeh HosseinzadehDaniel Schlenk
May 9, 2016·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·L Cody SmithTara Sabo-Attwood
Jul 4, 2020·Molecular and Cellular Endocrinology·Xiao-Min RenBruce Blumberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.