PMID: 6165991Jan 1, 1981Paper

Estimation of evolutionary distances between homologous nucleotide sequences

Proceedings of the National Academy of Sciences of the United States of America
M Kimura

Abstract

By using two models of evolutionary base substitutions--"three-substitution-type" and "two-frequency-class" models--some formulae are derived which permit a simple estimation of the evolutionary distances (and also the evolutionary rates when the divergence times are known) through comparative studies of DNA (and RNA) sequences. These formulae are applied to estimate the base substitution rates at the first, second, and third positions of codons in genes for presomatotropins, preproinsulins, and alpha- and beta-globins (using comparisons involving mammals). Also, formulae for estimating the synonymous component (at the third codon position) and the standard errors are obtained. It is pointed out that the rates of synonymous base substitutions not only are very high but also are roughly equal to each other between genes even when amino acid-altering substitution rates are quite different and that this is consistent with the neutral mutation-random drift hypothesis of molecular evolution.

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Citations

Jun 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Easteal
Oct 1, 1989·Plant Molecular Biology·M StranathanJ L Zimmerman
Sep 1, 1994·Journal of Molecular Evolution·A Zharkikh
May 1, 1992·Journal of Molecular Evolution·B J Smith-White, J Preiss
Jan 1, 1996·Journal of Molecular Evolution·V Kapitonov, J Jurka
Jan 1, 1995·Immunogenetics·B L SlierendregtR E Bontrop
Jan 1, 1982·Journal of Molecular Evolution·T GojoboriD Graur
Jan 1, 1984·Journal of Molecular Evolution·W J Wilbur
Jan 1, 1984·Journal of Molecular Evolution·G G BrownD P Verma
Jan 1, 1987·Journal of Molecular Evolution·W L GerlachM T Clegg
Jan 1, 1985·Journal of Molecular Evolution·M HasegawaT Yano
Jan 1, 1984·Journal of Molecular Evolution·C LanaveG Serio
Jul 1, 1989·Journal of Molecular Evolution·L E TalbertV L Chandler
Jan 1, 1987·Journal of Molecular Evolution·M M Smith
Jan 1, 1987·Journal of Molecular Evolution·G Preparata, C Saccone
Jan 1, 1987·Journal of Molecular Evolution·M Kimura
Jan 1, 1987·Journal of Molecular Evolution·T Gojobori, S Yokoyama
Jan 1, 1986·Journal of Molecular Evolution·W Bains
Jan 1, 1987·Journal of Molecular Evolution·S Yokoyama, T Gojobori
Jan 1, 1983·Journal of Molecular Evolution·R Holmquist
Apr 9, 2005·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·S TakahashiK Kadowaki
May 5, 2005·Journal of Molecular Evolution·Stephan KoblmüllerChristian Sturmbauer
Mar 25, 2009·Journal of Molecular Evolution·Alexis Criscuolo, Christian J Michel
Aug 2, 2007·Journal of Mathematical Biology·Manuel E LladserRob Knight
Dec 6, 2011·Journal of Mathematical Biology·Vincent Moulton, Mike Steel
Feb 10, 2009·Bulletin of Mathematical Biology·Jacques M Bahi, Christian J Michel

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