Estimation of genetic parameters and detection of chromosomal regions affecting the major milk proteins and their post translational modifications in Danish Holstein and Danish Jersey cattle

BMC Genetics
Bart BuitenhuisL B Larsen

Abstract

In the Western world bovine milk products are an important protein source in human diet. The major proteins in bovine milk are the four caseins (CN), αS1-, αS2-, β-, and k-CN and the two whey proteins, β-LG and α-LA. It has been shown that both the amount of specific CN and their isoforms including post-translational modifications (PTM) influence technological properties of milk. Therefore, the aim of this study was to 1) estimate genetic parameters for individual proteins in Danish Holstein (DH) (n = 371) and Danish Jersey (DJ) (n = 321) milk, and 2) detect genomic regions associated with specific milk protein and their different PTM forms using a genome-wide association study (GWAS) approach. For DH, high heritability estimates were found for protein percentage (0.47), casein percentage (0.43), k-CN (0.77), β-LG (0.58), and α-LA (0.40). For DJ, high heritability estimates were found for protein percentage (0.70), casein percentage (0.52), and α-LA (0.44). The heritability for G-k-CN, U-k-CN and GD was higher in the DH compared to the DJ, whereas the heritability for the PD of αS1-CN was lower in DH compared to DJ, whereas the PD for αS2-CN was higher in DH compared to DJ. The GWAS results for the main milk proteins were in li...Continue Reading

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Citations

Jan 15, 2018·Journal of Dairy Science·Qiuyu Wang, Henk Bovenhuis
Jun 11, 2019·Journal of Dairy Science·A BenedetJ E Pryce
Jan 19, 2020·Animals : an Open Access Journal From MDPI·Chao DuShujun Zhang
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Nov 11, 2020·Molecular Biology and Evolution·Yun-Hua LoWen-Ya Ko
Feb 24, 2021·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Wanting DongLi Jiang
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May 25, 2021·Food Science & Nutrition·Kong Yang WuQuan Yang Li
Jul 22, 2021·Genetics, Selection, Evolution : GSE·Kathryn M TipladyMathew D Littlejohn
Oct 28, 2021·Tropical Animal Health and Production·Carolina Guimarães Ramos MatosinhoMaria Raquel Santos Carvalho

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Methods Mentioned

BETA
glycosylation
infrared
flow cytometry
chips
chip

Software Mentioned

haploview
METAL
R package “ qvalue
Beadstudio
R
DGAT
plink
GenCall
iScan
REML

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