Estimation of glomerular filtration rate in cancer patients with abnormal body composition and relation with carboplatin toxicity

Cancer Chemotherapy and Pharmacology
M BretagneJ Alexandre

Abstract

Carboplatin clearance is correlated with glomerular filtration rate (GFR) and usually estimated with creatinine clearance using Cockcroft-Gault (CG) formula. Because plasma creatinine level is highly correlated with muscle mass, we hypothesized that an abnormal body composition with a low lean body mass (LBM) percentage [(LBM/weight) × 100] may result in inadequate carboplatin dosing. Serum cystatin C is an alternative marker of GFR, not affected by muscle mass. We aimed to investigate the influence of total LBM and LBM percentage on GFR calculation, using creatinine (CrCl) or cystatin C (GFRcysC-creat) in cancer patients. Pretreatment serum creatinine and cystatin C were prospectively measured in consecutive patients. CrCl (CG formula), GFRcysC-creat (CKD-EPI creatinine-cystatin equation), and LBM (CT scan) were calculated. Severe thrombocytopenia post-carboplatin were analyzed. In 131 patients without renal insufficiency, LBM was correlated with creatinine (r = 0.30, p < 0.005) but not with cystatin C (r = -0.07, p = 0.43). In patients with the lowest LBM percentage, the CrCl was significantly higher than GFRcysC-creat indicating an overestimation of GFR with creatinine (p = 0.0004). In 24 patients treated with carboplatin AU...Continue Reading

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Citations

Mar 30, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M JoannidisA Zarbock
Jul 6, 2020·Clinical and Experimental Nephrology·Yoshihiro UekuzuMasanobu Usui
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Jul 28, 2020·Lancet·Jolanta MalyszkoAnna Capasso
Sep 25, 2021·EJNMMI Research·Jessie HanDimitrios C Karampinos

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