Estimation of Hepatitis C Disease Burden and Budget Impact of Treatment Using Health Economic Modeling

Infectious Disease Clinics of North America
Jagpreet ChhatwalRakesh Aggarwal

Abstract

Oral direct-acting antiviral agents have revolutionized treatment of hepatitis C virus (HCV) infection. Nonetheless, barriers exist to elimination of HCV as a public health threat including low uptake of treatment, limited budget allocations for HCV treatment, and low awareness rates of HCV status among infected people. Mathematical modeling provides a systematic framework to analyze and compare potential solutions and elimination strategies by simulating the HCV epidemic under different conditions. Such models evaluate impact of interventions in advance of implementation. This article describes key components of developing an HCV burden model and illustrates its use by simulating the HCV epidemic in the United States.

Citations

Nov 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Megan G HofmeisterA Blythe Ryerson
Apr 28, 2019·International Journal of Clinical Pharmacy·María Ángeles Campos Fernández de SevillaIrene Iglesias-Peinado
May 11, 2019·JAMA Network Open·Jagpreet ChhatwalFasiha Kanwal
Apr 10, 2020·MMWR. Morbidity and Mortality Weekly Report·A Blythe RyersonCarolyn Wester
Mar 7, 2020·Hepatology Communications·Heather BradleyEli S Rosenberg
Apr 20, 2021·Clinical Liver Disease·Madeline AdeeJagpreet Chhatwal

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