Estimation of left ventricular pressure with the pump as "sensor" in patients with a continuous flow LVAD

The International Journal of Artificial Organs
Kim A M A PenningsMarcel C M Rutten

Abstract

In long-term ventricular support of patients with LVADs, left ventricular pressure (p(lv)) is relevant for indicating the unloading level of the heart. Monitoring of p(lv) over time might give more insight into the increase or decrease in native ventricular function. In this study, we aim to assess dynamic p(lv) noninvasively, using the LVAD as a pressure sensor. Pressure head (dp(lvad)) was estimated from pump flow with a dynamic pump model (1). Estimated dp(lvad) and measured aortic pressure were used to calculate left ventricular pressure. Moreover, parameters dp/dtmax and mean, minimum, and maximum p(lv) were derived.The method was validated with a porcine ex vivo beating heart model by measurements conducted in 4 hearts supported with a Micromed DeBakey VAD and 3 hearts with a Heartmate II VAD. During each measurement, aortic and left ventricular pressure, pump flow, and pressure head were recorded for 30 s with a sampling frequency of 1 kHz. The estimation of left ventricular pressure appeared to be accurate for both pumps. The parameters mean and minimum pressure were estimated with high accuracy. The degree of accuracy of the estimated p(lv) was proportional to the degree of accuracy of the dynamic pump model. We proved...Continue Reading

References

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Citations

Aug 5, 2017·The International Journal of Artificial Organs·Guang-Mao LiuXing-Min Gui
Oct 18, 2019·The International Journal of Artificial Organs·Benjamin KapplerBas Ajm de Mol
Aug 16, 2016·The International Journal of Artificial Organs·Andrea Remuzzi
Apr 4, 2020·Artificial Organs·Louis S FixsenRichard G P Lopata

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