Estimation of melanin and hemoglobin in skin tissue using multiple regression analysis aided by Monte Carlo simulation

Journal of Biomedical Optics
Izumi NishidateHiromichi Mishina

Abstract

To estimate the concentrations of melanin and blood and the oxygen saturation in human skin tissue, we propose a method using a multiple regression analysis aided by a Monte Carlo simulation for diffuse reflectance spectra from the skin tissue. By using the absorbance spectrum as a response variable and the extinction coefficients of melanin, oxygenated hemoglobin, and deoxygenated hemoglobin as predictor variables, the multiple regression analysis gives regression coefficients. The concentrations of melanin and blood are determined from the regression coefficients using conversion vectors that are estimated numerically in advance, while the oxygen saturation is obtained directly from the regression coefficients. Numerical and experimental investigations were performed for layered skin tissue models and phantoms. Measurements of human skin were also carried out to monitor variations in the melanin and blood contents and oxygenation during cuff occlusion. The results confirmed the usefulness of the proposed method.

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Citations

Jan 21, 2010·Lasers in Medical Science·Tom ListerPaul Chappell
Sep 8, 2011·Journal of Biomedical Optics·Izumi NishidateKyuichi Niizeki
Oct 23, 2012·Journal of Biomedical Optics·Dmitry YudovskyAnthony J Durkin
Nov 13, 2007·Journal of Biomedical Optics·Izumi NishidateKyuichi Niizeki
Mar 5, 2008·Journal of Biomedical Optics·Sheng-Hao TsengAnthony J Durkin
Feb 2, 2013·Facial Plastic Surgery Clinics of North America·Marty O Visscher, Brian S Pan
May 5, 2016·International Journal of Computer Assisted Radiology and Surgery·Sebastian J WirkertLena Maier-Hein
Dec 15, 2011·Journal of Biophotonics·Julia L Sandell, Timothy C Zhu
Jul 2, 2016·Journal of Biomedical Optics·Jihoon ParkByungjo Jung
Jul 20, 2010·Optics Express·M KoetsierReindert Graaff
Jan 20, 2012·Physiological Measurement·Oleg KimMark Alber
Oct 19, 2017·Optics Express·C M GohF Meriaudeau
Oct 3, 2008·Optics Letters·Izumi NishidateYoshihisa Aizu
Aug 19, 2009·Optics Express·Sheng-Hao TsengNikiforos Kollias
Aug 5, 2017·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·S-Y TzengS-H Tseng
Jun 4, 2019·Applied Optics·Hongyu ChenRonald X Xu
Feb 7, 2021·International Journal of Molecular Sciences·Fahima KhatunIzumi Nishidate
Feb 16, 2021·Frontiers in Physiology·Kenichiro Yoshida, Izumi Nishidate
Jul 11, 2021·The Review of Scientific Instruments·C BlaksleyG Cambié

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