PMID: 2511788Jan 1, 1989Paper

Estimation of peripheral chemoreflex gain from spontaneous sigh responses

Annals of Biomedical Engineering
M C Khoo, V Z Marmarelis

Abstract

A method is proposed for quantifying the responsiveness of the peripheral chemoreflex loop to CO2 by utilizing the natural fluctuations in ventilation and end-tidal PCO2 which occur subsequent to the appearance of spontaneous sighs. The advantage of this method lies in its simplicity and noninvasiveness: the need for administering inhaled mixtures with high CO2 content is eliminated. Using autoregressive moving-average (ARMA) analysis, we demonstrate that post-sigh responses can be adequately described by a simple chemoreflex model that contains first-order dynamics and a pure time delay. The effective gain of this model is shown to reflect peripheral chemosensitivity closely when the estimation procedure is applied to 'data' obtained from computer simulations of the respiratory control system. Although central chemosensitivity affects the absolute values of effective gain, the slope of the linear correlation between effective and peripheral gains remains unchanged. Application of the procedure to spontaneously breathing anesthetized dogs shows that, in every case, effective gain increased with the induction of hypoxia, which is known to enhance peripheral chemosensitivity.

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Citations

Jan 14, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Karen A BrownRobert E Kearney
Apr 12, 2001·Biological Psychiatry·F H WilhelmW T Roth
Apr 9, 2011·Journal of Applied Physiology·Shamim NematiJames P Butler
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Joost G Van den Aardweg, John M Karemaker
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Eugene N Bruce
May 28, 2011·American Journal of Respiratory and Critical Care Medicine·Suvimol SangkatumvongThomas D Coates
Jul 20, 2014·Respiratory Physiology & Neurobiology·Elnaz GederiAndrew Wellman
Jul 10, 2001·IEEE Transactions on Bio-medical Engineering·B BouferracheJ P Libert
Jan 13, 2018·American Journal of Respiratory and Critical Care Medicine·Keren Armoni DomanyRaouf S Amin
Oct 18, 2014·The European Respiratory Journal·Philip I TerrillScott A Sands
Sep 24, 2005·Journal of Applied Physiology·Ailiang XieJerome A Dempsey
Feb 7, 2009·Journal of Applied Physiology·G D MitsisK T S Pattinson
Feb 14, 2009·Journal of Applied Physiology·Joost G van den Aardweg
Sep 18, 1997·Journal of Applied Physiology·M Sammon, F Curley

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