Estimation of phosphene spatial variability for visual prosthesis applications

Artificial Organs
Iyad ObeidJ Delbeke

Abstract

Visual prostheses are the focus of intensive research efforts to restore some measure of useful vision to blind or near-blind patients. The development of such technology is being guided to an extent by tools that simulate prosthesis behavior for healthy sighted subjects in order to assess system requirements and configurations. These simulators, however, typically assume purely deterministic phosphene properties and thus do not apply any variability to phosphene size, intensity, or location. We address this issue by presenting data on phosphene variability measured in a blind human subject fitted with an optic nerve prosthesis. In order to correct for normal limitations in human-pointing accuracy, the experimental conditions were repeated with sighted subjects. We conclude that identical optic nerve stimulations can result in phosphenes whose perceived locations vary by up to 5 degrees of deviation angle and 10 degrees of position angle. The consistency of phosphenes presented in the peripheral field of view can vary by an additional 3 degrees.

References

Jul 1, 1992·Vision Research·K ChaR A Normann
May 1, 1992·Journal of the Optical Society of America. A, Optics and Image Science·K ChaD K Boman
May 1, 1968·The Journal of Physiology·G S Brindley, W S Lewin
Apr 10, 2002·Artificial Organs·Jean DelbekeC Veraart
Jan 22, 2003·Vision Research·Jörg SommerhalderMarco Pelizzone
Sep 18, 2003·Vision Research·Mark S HumayunEugene de Juan
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Robert W ThompsonGislin Dagnelie
Nov 18, 2003·Artificial Organs·Claude VeraartJean Delbeke
Nov 18, 2003·Artificial Organs·Jasmine S HayesGislin Dagnelie
Nov 26, 2003·Investigative Ophthalmology & Visual Science·Joseph F RizzoDoug Shire
Apr 14, 2004·Archives of Ophthalmology·Alan Y ChowRonald Schuchard
Sep 17, 2004·Experimental Aging Research·Martin LemayGeorge E Stelmach
Jan 11, 2005·Vision Research·Luke E HallumNigel H Lovell
May 7, 2005·Journal of Neural Engineering·M E BrelénC Veraart
Jul 26, 2005·Experimental Brain Research·Sukhvinder S Obhi, Melvyn A Goodale
Oct 5, 2005·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Spencer C ChenGregg J Suaning
Jan 18, 2006·Medical & Biological Engineering & Computing·M OozeerJ Delbeke
Apr 20, 2006·Journal of Neurosurgery·Mårten E BrelénJean Delbeke
Apr 15, 2009·Archives of Ophthalmology·Avi CaspiMatthew J McMahon
May 22, 2009·Journal of Neural Engineering·N B DommelG J Suaning
May 22, 2009·Journal of Neural Engineering·Richard A NormannEduardo Fernandez

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Citations

Mar 16, 2011·Artificial Organs·Paul S Malchesky

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