Estimation of pressure pulse amplification between aorta and brachial artery using stepwise multiple regression models

Physiological Measurement
F CamachoN H Lovell

Abstract

The pressure pulse is amplified between the aorta and peripheral sites. This study compares two methods to estimate pressure pulse amplification (PPA) between the aorta and the brachial artery. Method 1: PPA was determined from a multi-parameter linear regression of subject parameters (gender, age, height, weight, heart rate (HR), brachial systolic pressure (BSP), diastolic pressure (BDP), mean pressure (MP)). Method 2: PPA was calculated from central aortic pressure waveforms (CW) estimated from the same subject parameters. The sample population (1421 male, 992 female) was selected from a database where aortic pressure was estimated by mathematical transformation of a peripheral (radial) pulse calibrated to sphygmomanometric BSP and BDP. The two methods were consistent in showing HR and MP as the most important parameters to estimate PPA. Correlation coefficients (R2) of 0.48 (method 1) and 0.44 (method 2) were obtained using height, weight, HR, BSP, BDP and age. Inclusion of MP increased R2 to 0.77 (method 1) and 0.71 (method 2). This study shows that databases containing peripheral and central aortic pressure waveforms can be used to construct multiple regression models for PPA estimation. These models could be applied to st...Continue Reading

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Citations

Jul 16, 2009·Current Hypertension Reports·Carmel M McEniery
Jan 25, 2014·European Heart Journal·Carmel M McEnieryIan B Wilkinson
May 1, 2010·Journal of Cardiovascular Computed Tomography·Naser AhmadiMatthew Budoff
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Mar 25, 2019·Nature Biomedical Engineering·Chonghe WangSheng Xu

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