Estimation of probability of malignancy using a logistic model combining color Doppler ultrasonography, serum CA125 level in women with a pelvic mass

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
A S MousaviS Moeinoddini

Abstract

The goal of this study was to develop a scoring system using combination of Doppler characterization of pelvic/ovarian lesions and serum CA125 level. Our purpose was to maximize the preoperative discrimination between benign and malignant entities. In a prospective study, a total of 101 patients were evaluated preoperatively using a standard transvaginal ultrasound and color Doppler imaging with pulse spectral analysis and serum CA125 level within a week prior to surgery. The variables that were analyzed by the multivariate logistic regression method are as follows: tumor structure, ascites, presence of septum, the peak systolic velocity (PSV), the resistance index (RI), and serum CA125 level. Of the 101 patients qualified for the study, 48 patients were diagnosed with benign (47.5%) and 53 (52.5%) with malignant tumors. Each criterion used alone provides statistically significant discrimination between benign and malignant tumors. Four criteria could be combined in a malignancy score which is calculated using the product of the serum CA125 level (1 if CA125 > or =40 U/mL and 0 if CA125 <40 U/mL), the result of sonography for presence of septum in tumor (1 if there was septum > or =3 mm, 0 if there was no septum or <3 mm), resu...Continue Reading

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Citations

Aug 10, 2012·Current Oncology·J E DodgeUNKNOWN Gynecology Cancer Disease Site Group
Mar 19, 2013·Journal of Clinical Ultrasound : JCU·Lisa BarroilhetBeryl Benacerraf
Apr 27, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M LabanG Mansour
Jan 24, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Maciej StukanJacek P Grabowski
Jan 22, 2009·Obstetrics and Gynecology·Peggy GeominiBen W J Mol
Jul 22, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Charuwan TantipalakornTheera Tongsong

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