Estimation of radioactivity in single-photon emission computed tomography for sentinel lymph node biopsy in a torso phantom study

Nuclear Medicine Communications
Hideaki KitamuraMasahiro Fukushi

Abstract

The number of lymph nodes to be removed is determined from residual counts. Advance estimation of residual radioactivity in lymphatic nodes before a biopsy is useful for reducing surgical operation time. The purpose of this study was to estimate the total radioactivity of a small hotspot in single-photon emission computed tomography (SPECT) of a torso phantom. A cross-calibration study was performed to convert counts in SPECT images to radioactivity. A simulation study was performed to estimate the size of the volume of interest (VOI) covering a hotspot corrupted with full-width at half-maximum between 8 and 16 mm. The estimation of total radioactivity was validated in a torso phantom study using small sources. True radioactivity was approximately equal to integrated values of hotspots using the VOI with a diameter of 40 mm in our simulation study. The difference was less than 18% in cases of more than 9.4 kBq. The total radioactivity in small sources simulating a typical sentinel node was estimated from SPECT images using a VOI of 40 mm in a torso phantom study. Because the difference from actual values was less than 10% on average when radioactivities were more than 9.4 kBq, the total radioactivity of a lymph node can be esti...Continue Reading

References

Oct 19, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Iris M C van der PloegCornelis A Hoefnagel
Feb 22, 2008·Journal of Nuclear Medicine Technology·James A Patton, Timothy G Turkington
Apr 9, 2008·Seminars in Nuclear Medicine·Youngho SeoBruce H Hasegawa
May 23, 2008·Physics in Medicine and Biology·Kathy WillowsonClive Baldock
Aug 6, 2008·Physics in Medicine and Biology·S ShcherbininA Driedger
Sep 5, 2008·Nuclear Medicine Communications·Ivan A Ho ShonJohn F Thompson
Nov 20, 2009·Journal of Surgical Oncology·Lenka VermeerenOmgo E Nieweg
May 21, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Johannes ZeintlTorsten Kuwert
Sep 18, 2010·Head & Neck·Lenka VermeerenMichiel W M van den Brekel
Apr 13, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Philipp RittTorsten Kuwert
Jul 11, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra L WongUNKNOWN Society of Surgical Oncology
Jan 2, 2013·Nuclear Medicine Communications·Thomas WagnerShaunak Navalkissoor

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