PMID: 374826Nov 1, 1978Paper

Estimation of relative glomerular capillary surface area in normal and hypertrophic rat kidneys

Kidney International
D W KnutsonR J Glassock

Abstract

The quantity of antiglomerular baSEMent membrane antibodies (antiGBM) binding to the glomeruli of rats 4 hr after i.v. injection of 660 microgram of antiGBM was used as a measure of relative glomerular capillary surface area (Sr). Intact immature and adult rats (N = 27) weighing 46 to 440 g were studied to assess the effect of normal growth on Sr. Young adult rats (N = 36) were studied at 0, 8, 15, and 22 days following uninephrectomy or sham operation to assess the effect of hypertrophic kidney growth on Sr. Bound antiGBM increased from 95 microgram to approximately 350 microgram as rats grew from 46 to 200 g; further growth was associated with no further growth was associated with no further increases in bound antiGBM. In contrast, there was no progressive increase in Sr following uninephrectomy or sham operation despite as 45% increase in kidney weight at 22 days over the comparable kidney in the sham-operated rats (1.32 +/- SEM 0.06 g vs. 0.91 +/- SEM 0.01 g, P less than 0.0001). Thus, increases in GFR during early normal kidney growth parallel anatomic increases in Sr, but increases in GFR with later growth or with compensatory hypertrophy in young adult rats are not accompanied by changes in Sr.

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Citations

Jul 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G CelsiA Aperia
Jan 1, 1982·Pharmacology & Therapeutics·B Noordewier, J B Hook
Mar 1, 1997·Renal Failure·W M Bennett
Dec 1, 1990·Kidney International·T IshidateJ R Hoyer
Feb 1, 1988·Kidney International·A YaredI Ichikawa
Nov 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Apr 11, 2019·Physiology·Hadi FattahVolker Vallon
Jan 1, 1980·Journal of Immunological Methods·M Stuffers-HeimanL A Van Es

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