Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Bh CharitaT Padma

Abstract

The risk conferred by the variants and haplotypes of single nucleotide polymorphisms (SNPs) at human angiotensinogen (AGT) gene to essential hypertension (EHT) have been described in several populations with variations in the results attributed to their ethnicity. We attempted to evaluate the risk of -217G>A, -152G>A, -20A>C, -6G>A, T174M, M235T and 15241A>G polymorphisms at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to EHT. Two-hundred and forty-nine hypertensives and 248 controls were genotyped for the selected markers. Study of demographic parameters revealed significant association of obesity, positive family history and non-vegetarian diet habit, suggesting elevated risk of the condition when associated with these parameters. Significantly high risk for males with AA genotype of -217G>A polymorphism was observed for developing EHT (p = .07). Males with -217A (p = .01) showed a two-fold higher risk for EHT. Markers -217G>A and -6G>A were in strong linkage disequilibrium in patients as compared to controls. Strong epistatic interactions were found between -6G>A, M235T and -217G>A markers, supporting the synergistic effect between them leading to EHT. Our findings sugge...Continue Reading

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Jan 1, 1971·Cardiovascular Research·A B Gould, D Green
Mar 1, 1982·Hypertension·J GardesJ Menard
Aug 1, 1995·The Journal of Clinical Investigation·M CaulfieldA J Clark
Apr 1, 1995·Hypertension·N IwaiM Kinoshita
Oct 20, 1994·The New England Journal of Medicine·M J Brown, D Clayton
Mar 1, 1994·The Journal of Clinical Investigation·A HataJ M Lalouel
Jun 9, 1994·The New England Journal of Medicine·M CaulfieldA J Clark
Dec 15, 1993·Biochemical and Biophysical Research Communications·C L BennettB J Morris
Jun 1, 1997·American Journal of Human Genetics·X JeunemaitreJ M Lalouel
Feb 14, 1998·The Journal of Clinical Investigation·T NiuK Lindpaintner
Jul 4, 2001·Journal of Epidemiology·T KishimotoS Fukumoto
Jul 11, 2002·Annals of Medicine·Jason H Moore, Scott M Williams
Aug 10, 2002·Journal of Cellular and Molecular Medicine·Lucia ProcopciucD Zdrenghea
Aug 21, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F J ChavesJ Redon
Jan 4, 2003·Hypertension·Alexandre C PereiraJosé E Krieger
Apr 16, 2003·Hypertension·Xiaofeng ZhuAravinda Chakravarti

❮ Previous
Next ❯

Citations

May 27, 2014·BioMed Research International·Kh Dhanachandra SinghMuthusamy Karthikeyan
Feb 5, 2014·Clinical and Experimental Hypertension : CHE·G PadmaT Padma
Jun 22, 2016·Heart Asia·Samantha KohliM A Qadar Pasha
Oct 21, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A V IvanovE V Komlichenko
Jul 12, 2016·Clinical and Experimental Hypertension : CHE·Padma GundaPadma Tirunilai
Mar 10, 2018·The Journal of Clinical Hypertension·Yandiswa Y YakoAndre P Kengne

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
electrophoresis

Software Mentioned

statistical package for social sciences ( SPSS )
MDR
Haploview

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.