Estimation of the amount of water removed by gap and atomization air streams during pelletization in a rotary processor

Pharmaceutical Development and Technology
J VertommenR Kinget

Abstract

The purpose of this study was to estimate the amount of water removed by the gap and atomization air streams during pelletization by the wet granulation technique in a rotary processor and to test the hypothesis that the influence of the water addition rate on the pellet size (1,7) mainly originates from differences in the amount of water removed by these air streams. Estimations from flow, temperature, and relative humidity measurements of the air streams, and estimations from moisture content measurements, indicated that approximately 3.6 g of water/min was removed during spheronization. The estimations from the air streams' characteristics obtained for the water loss during the water addition phase (2.6 g/min) reflected the water removal during the later stages and did not reflect the overall rate of water removal during the total water addition phase as estimated from moisture content measurements (2.0 g/min). This was attributed to the fact that estimations from the air streams' characteristics could not take into account the early stages of the water addition phase. In these early stages, the amount of water removed was very limited. Using the foregoing estimations, differences in amount of water removed by the air stream...Continue Reading

References

Dec 1, 1996·Pharmaceutical Development and Technology·J VertommenR Kinget

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Citations

Apr 20, 2004·Drug Development and Industrial Pharmacy·L GuP W S Heng
Apr 3, 2009·Journal of Pharmaceutical Sciences·Rahul Dixit, Shivanand Puthli
May 16, 2000·Pharmaceutical Development and Technology·J RantanenJ Yliruusi
May 16, 2000·Pharmaceutical Development and Technology·J KristensenP Kleinebudde
Jan 1, 2012·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Walid F SakrAdel A Sakr
Apr 6, 2007·AAPS PharmSciTech·Celine V LiewPaul W S Heng

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