Estimation of the bone mineral density variation associated with changes in turnover rate

Calcified Tissue International
C P Jerome

Abstract

Bone matrix mineral density (BMDn, fraction of maximum) is the mean mineral density of a bone sample comprising moieties of bone of varying ages/mineral densities. A method for calculating BMDn as a function of bone turnover rate is presented. The method is based on a mineralization curve defined by values for mineralization lag time, total mineralization time, and levels of primary and final mineralization. The calculations illustrate that BMDn decreases linearly in direct proportion to increases in bone turnover rate, and that the slope of the line is dependent on the assumptions used to calculate the mineralization curve. BMDn variation is important because it is reflected in whole bone density variation, independent of changes in bone mass, when bone turnover rate is altered.

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Citations

Dec 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C HaslingJ Risteli
Oct 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R P Heaney
Sep 19, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·K BrixenL Mosekilde
Aug 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R P HeaneyA C Santora
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H M Frost
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K BrixenF Melsen
Sep 22, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Robyn K FuchsDavid B Burr
Jul 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Davide RuffoniRichard Weinkamer
Sep 26, 2003·Calcified Tissue International·J C van der LindenH Weinans
Nov 1, 1996·European Journal of Haematology·N AbildgaardJ L Nielsen

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