Estimation of the burden of varicella in Europe before the introduction of universal childhood immunization

BMC Infectious Diseases
Margarita Riera-MontesSusanne Hartwig

Abstract

Varicella is generally considered a mild disease. Disease burden is not well known and country-level estimation is challenging. As varicella disease is not notifiable, notification criteria and rates vary between countries. In general, existing surveillance systems do not capture cases that do not seek medical care, and most are affected by underreporting and underascertainment. We aimed to estimate the overall varicella disease burden in Europe to provide critical information to support decision-making regarding varicella vaccination. We conducted a systematic literature review to identify all available epidemiological data on varicella IgG antibody seroprevalence, primary care and hospitalisation incidence, and mortality. We then developed methods to estimate age-specific varicella incidence and annual number of cases by different levels of severity (cases in the community, health care seekers in primary care and hospitals, and deaths) for all countries belonging to the European Medicines Agency (EMA) region and Switzerland. In the absence of universal varicella immunization, the burden of varicella would be substantial with a total of 5.5 million (95% CI: 4.7-6.4) varicella cases occurring annually across Europe. Variation e...Continue Reading

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Citations

Mar 6, 2018·PloS One·Snežana MedićCleo Anastassopoulou
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Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

EUVAC
MS Excel
PRISMA
NET

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