Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice

Molecular Medicine Reports
Hyun YangEui-Bae Jeung

Abstract

Aromatherapy has been suggested as an alternative therapeutic method for the treatment of atopic dermatitis (AD), eczema and other skin diseases. In the current study, the anti-atopic properties of the volatile organic compounds of Chamaecyparis obtusa (VOCCo) were examined to determine whether they are amenable for use as a pharmaceutical candidate. The alterations in histological features, serum IgE levels and mast cell infiltration following exposure to VOCCo were determined in a 2,4-dinitrochlorobenzene (DNCB)-induced AD-like mouse model. The results of these experiments demonstrated that VOCCo inhibited the development of AD-like skin lesions by reducing the serum IgE level and mast cell infiltration into the dermal and subcutaneous layers. This was supported by screening of immune cytokine mRNAs, including interleukin (IL)-1β and IL-6 from the skin of DNCB-treated mice. The expression of IL-1β and IL-6 in the skin lesions of mice was dose-dependently inhibited by treatment with VOCCo. Furthermore, treatment with VOCCo resulted in the recovery of histopathological features in AD-like skin lesions. These results suggest that VOCCo may have therapeutic and preventive effects for the development of AD.

References

Jan 1, 1997·International Archives of Occupational and Environmental Health·G WieslanderG Boman
Feb 9, 2002·International Journal of Hygiene and Environmental Health·I LehmannUNKNOWN Leipzig Allergy Risk Children Study
Apr 30, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Thaçi
Mar 3, 2004·The Journal of Clinical Investigation·Donald Y M LeungQutayba A Hamid
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Eui-Ju HongEui-Bae Jeung
Jun 22, 2005·Journal of the American Academy of Dermatology·William Abramovits
Dec 2, 2005·The European Respiratory Journal·S N GeorasV Casolaro
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Nobuko ShimizuTetsuo Kaneko
Mar 27, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Mari KawaiToshio Tanaka
Nov 26, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dongsun ParkSeong Soo Joo
Jun 21, 2011·Immunological Reviews·Mark Boguniewicz, Donald Y M Leung
Dec 15, 2012·Pharmacological Reports : PR·Weimin WangKeqin Zou
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ju-Hyun GongYoung-Hee Kang
Jun 14, 2013·Journal of the American Academy of Dermatology·Hsiewe Ying TanGeorge Binh Lenon
Oct 15, 2013·Allergy·S C DharmageM J Abramson

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Citations

Jan 27, 2019·Experimental and Therapeutic Medicine·Iulia SolomonSabina Zurac
Oct 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung-Heon ShinMi-Hyun Che
Feb 7, 2021·International Journal of Environmental Research and Public Health·Liisa AndersenUlrika Karlsson Karlsson Stigsdotter

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