Abstract
Aromatherapy has been suggested as an alternative therapeutic method for the treatment of atopic dermatitis (AD), eczema and other skin diseases. In the current study, the anti-atopic properties of the volatile organic compounds of Chamaecyparis obtusa (VOCCo) were examined to determine whether they are amenable for use as a pharmaceutical candidate. The alterations in histological features, serum IgE levels and mast cell infiltration following exposure to VOCCo were determined in a 2,4-dinitrochlorobenzene (DNCB)-induced AD-like mouse model. The results of these experiments demonstrated that VOCCo inhibited the development of AD-like skin lesions by reducing the serum IgE level and mast cell infiltration into the dermal and subcutaneous layers. This was supported by screening of immune cytokine mRNAs, including interleukin (IL)-1β and IL-6 from the skin of DNCB-treated mice. The expression of IL-1β and IL-6 in the skin lesions of mice was dose-dependently inhibited by treatment with VOCCo. Furthermore, treatment with VOCCo resulted in the recovery of histopathological features in AD-like skin lesions. These results suggest that VOCCo may have therapeutic and preventive effects for the development of AD.
References
Jan 1, 1989·The Journal of Experimental Medicine·F P HeinzelR M Locksley
Apr 1, 1994·Contact Dermatitis·J L GarrigueD Schmitt
Jan 1, 1997·International Archives of Occupational and Environmental Health·G WieslanderG Boman
Feb 18, 1998·Immunology Today·S Grabbe, T Schwarz
Aug 24, 2000·International Journal of Hygiene and Environmental Health·U DiezO Herbarth
Dec 19, 2001·Journal of Korean Medical Science·Y J SurhY S Keum
Feb 9, 2002·International Journal of Hygiene and Environmental Health·I LehmannUNKNOWN Leipzig Allergy Risk Children Study
Apr 30, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Thaçi
Mar 3, 2004·The Journal of Clinical Investigation·Donald Y M LeungQutayba A Hamid
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Eui-Ju HongEui-Bae Jeung
Jul 13, 2004·Allergy·E J Bardana
Jan 29, 2005·The Prostate·Soo Ok LeeAllen C Gao
Jun 22, 2005·Journal of the American Academy of Dermatology·William Abramovits
Dec 2, 2005·The European Respiratory Journal·S N GeorasV Casolaro
Aug 22, 2006·International Immunopharmacology·Jong Soon KangHwan Mook Kim
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Nobuko ShimizuTetsuo Kaneko
Mar 27, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Mari KawaiToshio Tanaka
Nov 26, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dongsun ParkSeong Soo Joo
Sep 28, 2010·Journal of Dermatological Science·Seong Soo JooEui-Bae Jeung
Jun 21, 2011·Immunological Reviews·Mark Boguniewicz, Donald Y M Leung
Dec 15, 2012·Pharmacological Reports : PR·Weimin WangKeqin Zou
Jun 6, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ju-Hyun GongYoung-Hee Kang
Jun 14, 2013·Journal of the American Academy of Dermatology·Hsiewe Ying TanGeorge Binh Lenon
Oct 15, 2013·Allergy·S C DharmageM J Abramson
Citations
Nov 8, 2018·Biomedical Reports·Changhwan AhnEui-Bae Jeung
Jan 27, 2019·Experimental and Therapeutic Medicine·Iulia SolomonSabina Zurac
Oct 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung-Heon ShinMi-Hyun Che
Feb 7, 2021·International Journal of Environmental Research and Public Health·Liisa AndersenUlrika Karlsson Karlsson Stigsdotter
Dec 27, 2017·The Journal of Investigative Dermatology·Byung Eui KimDonald Y M Leung