PMID: 19137738Jan 14, 2009Paper

Estimation of the frequencies of induced mutations in spermatogenic cells of senescence-accelerated prone mice of the SAMP1 strain

Genetika
S T ZakhidovI A Zelenina

Abstract

The results obtained in this work demonstrate the dynamics of cytogenetic changes of spermatogenic cells in senescence-accelerated prone mice, strain SAMP1, after a single exposure to a chemical mutagen, dipin, at a genetically active dose of 30 mg/kg. In the time interval between days 3 and 28 the frequency of induced spermatogonial micronuclei does not significantly exceed the level of spontaneous mutagenesis. The lack of an experimental effect of micronuclei in this time interval is probably a consequence of mitotic delay and (or) of the death of a considerable part of genetically defective cells in the spermatogonial compartment. Different stages of meiosis exhibit different chemical sensibilities: the yield of round spermatids with micronuclei is maximum after treatment of early primary spermatocytes (preleptotene-leptotene stage) with dipin. The high sensibility of preleptotene and leptotene spermatocytes is confirmed by the sperm head shape abnormality assay. Chromosome damage caused by dipin in spermatogonial stem cells is irreversible, as evidenced by a sharp increase in the frequencies of spermatogonial and meiotic micronuclear aberrations within long periods after treatment. Increased genetic instability in the stem ...Continue Reading

References

Feb 1, 1986·Biology of Reproduction·M L Meistrich
Oct 1, 1981·Mechanisms of Ageing and Development·T TakedaT Yamamuro
Aug 26, 1998·International Journal of Experimental Pathology·D G de Rooij
Jan 19, 2000·Trends in Microbiology·R I CarpE A Sersen
Sep 16, 2000·Mechanisms of Ageing and Development·M HosokawaR K Zahn
Feb 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Masanori TakehashiTakashi Shinohara

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Citations

Apr 29, 2014·Bulletin of Experimental Biology and Medicine·T G BorovskayaP G Madonov
Sep 19, 2009·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·S T ZakhidovT L Marshak

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