Estimation of the glomerular filtration rate in NIDDM patients from plasma creatinine concentration after cimetidine administration

Diabetes Care
F A KempermanL Arisz

Abstract

Glomerular filtration rate (GFR) can be estimated in patients with renal disease from plasma creatinine concentration, age, sex, and body weight according to the formula of Cockcroft and Gault. The hypothesis that this method can be improved when tubular secretion of creatinine is inhibited by cimetidine was studied in NIDDM patients. In 30 outpatients with NIDDM and normo- (n = 10), micro- (n = 9), or macroalbuminuria (n = 11), GFR was measured as the urinary clearance during continuous infusion of 125I-labeled iothalamate. Plasma creatinine concentration was analyzed with an enzymatic assay before and after 800 mg t.i.d. oral cimetidine was given during a 24-h period. Plasma creatinine rose in all patients after cimetidine administration and, as a consequence, the clearance calculated with the Cockcroft-Gault formula fell. The ratio of this formula and GFR decreased from 1.16 +/- 0.20 to 0.97 +/- 0.16 (means +/- SD). This ratio tended to be smaller in the normo- (0.93) than in the micro- (0.98) and macroalbuminuric (1.00) groups. Also, 20 patients with a BMI < 30 kg/m2 had a smaller ratio than those with a BMI > 30 kg/m2 (0.92 vs. 1.07; P < 0.05). Bland and Altman analysis showed a difference of the Cockcroft-Gault formula an...Continue Reading

Citations

May 30, 2002·The American Journal of Medicine·Robert Matz
Jul 9, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marcelo CantarovichRenzo Cecere
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F A KempermanL Arisz
Feb 17, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amanda J W BrantenJack F M Wetzels
Jun 27, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Polina GermanAnita Mathias
Oct 16, 2012·Seminars in Nephrology·Matthew D Breyer
Sep 23, 2008·Metabolism: Clinical and Experimental·Vincent RigalleauHenri Gin
Apr 19, 2003·Journal of Internal Medicine·J C VerhaveP E de Jong
Oct 16, 1999·Annals of Internal Medicine·R Matz
Feb 27, 2009·The American Journal of Clinical Nutrition·Vincent RigalleauChristian Combe

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