Estimation of the glycation gap in diabetic patients with stable glycemic control.

Diabetes Care
Santiago Rodríguez-SegadeFélix Camiña

Abstract

The glycation gap (the difference between measured A1C and the value predicted by regression on fructosamine) is stable and is associated with microvascular complications of diabetes but has not hitherto been estimated within a clinically useful time frame. We investigated whether two determinations 30 days apart suffice for a reasonably reliable estimate if both A1C and fructosamine exhibit stability. We studied 311 patients with type 1 or type 2 diabetes for whom simultaneous measurements of A1C and serum fructosamine had been made on at least two occasions separated by 1 month (t(0) and t(1)). Glycemia was deemed stable if A1C(t(1)) - A1C(t(0)) and fructosamine(t(1)) - fructosamine(t(0)) were both less than their reference change values (RCVs). Instantaneous glycation gaps [gg(t(0)) and gg(t(1))] and their mean (GG), were calculated using the data from all stable patients for the required regression. Stable glycemia was shown by 144 patients. In 90% of unstable case subjects, a change in medication was identified as the cause of instability. Among 129 stable patients with an average of eight gg determinations prior to t(0), GG correlated closely with the mean of these prior determinations (r(2) = 0.902, slope 1.025, intercep...Continue Reading

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Citations

Jul 24, 2013·Analytical Biochemistry·James M HempeStuart A Chalew
Feb 19, 2014·Journal of Proteome Research·Pan Mao, Daojing Wang
Nov 5, 2014·Endocrine Journal·Junya AkatsukaUNKNOWN Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes
Nov 20, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nicholas B ArgentoPeter Simpson
Oct 27, 2014·Acta Diabetologica·Santiago Rodriguez-SegadeFélix Camiña
Nov 23, 2012·Diabetes Care·William T Cefalu, M Sue Kirkman
Nov 23, 2012·Diabetes Care·Robert M Cohen, Christopher J Lindsell
Nov 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Renata PaleariAndrea Mosca
Sep 25, 2018·Journal of Diabetes Science and Technology·Jennifer McKechnieGregory C Jones
Jan 15, 2019·Journal of Diabetes Science and Technology·Roy W BeckDavid Rodbard
Jul 18, 2019·Journal of General and Family Medicine·Masayuki Ikeda, Rumiko Shimazawa
May 11, 2019·Endocrine Reviews·Ananth U NayakSimon J Dunmore

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