Estimation of the half-life of a secretory protein message

Science
S Grayson, S J Berry

Abstract

Synthesis of a specific secretory protein was followed in the presence of actinomycin D and cordycepin (3'-deoxyadenosine). The apparent half-life of the messenger RNA for this protein is significantly longer in the presence of actinomycin D than in the presence of cordycepin. These results suggest that actinomycin D studies of half-life in specialized cells may be inaccurate.

References

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Citations

Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S M TilghmanF J Ballard
Feb 1, 1980·Wilhelm Roux's Archives of Developmental Biology·Herbert OberlanderFrank Van Essen

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