Estimation of the human intestinal permeability of butyltin species using the Caco-2 cell line model

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M A AzenhaM T Vasconcelos

Abstract

The main objective of the work was the setup of the Caco-2 human intestinal cell-line model for the study of the intestinal permeation of monobutyltin (MBT), dibutyltin (DBT) and tributyltin (TBT). The study was focused in gathering information on (a) the relative permeability of butyltins, (b) their possible permeation routes (paracellular/transcellular) and (c) the eventual interactions between the different butyltins when occurring as a mixture. The presence of basolateral serum protein greatly influenced the permeability, causing a large net clearance, but the apparent permeability (Papp) values were comparable to that of phenolred, suggesting a low in vivo permeability of the butyltins. The found permeability pattern correlates well with the general in vivo toxicity pattern (trialkyltin>dialkyltin>monoalkyltin). The accumulation pattern (DBT>TBT>MBT) was different from that of permeability and may be an important element regarding the elucidation of some specific strong toxic effects caused by the dialkyltins in several species. The transport of MBT and DBT was found to be dependent on the paracellular route status. An interaction between the butyltin compounds in a mixture was found for the accumulation results (the accum...Continue Reading

References

Sep 1, 1992·British Journal of Haematology·C LudescherJ Hofmann
Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchömigH Russ
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·W T Bellamy
Mar 4, 1999·Toxicology and Applied Pharmacology·E DuizerJ P Groten
Sep 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J KarlssonP Artursson
Dec 20, 1999·Journal of Agricultural and Food Chemistry·T SuzukiM Murayama
Nov 11, 1999·Human & Experimental Toxicology·A De Santiago, M Aguilar-Santelises
Sep 28, 2000·The Science of the Total Environment·M A Champ
Jun 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohamed El-SayedHamidreza Ghandehari

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Citations

May 26, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Adolf Michael SandbichlerBernd Pelster
Mar 24, 2012·Drug Development and Industrial Pharmacy·Jucimary V SantosLuís A E Batista de Carvalho
Dec 12, 2012·Reproductive Toxicology·Jones Bernardes GraceliMarcos Antonio Dos Santos Fernandez
Nov 13, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A AzenhaM T Vasconcelos
May 18, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rhonda M BrandSusan L Cuppett
Dec 13, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Alessandra PagliaraniVittoria Ventrella
Nov 7, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Woong Jae Park, Eunsook Ma
Apr 15, 2011·The Journal of Experimental Biology·Adolf Michael SandbichlerBernd Pelster
Nov 1, 2011·Trends in Food Science & Technology·Tomaz LangerholcAvrelija Cencic

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