PMID: 10922355Aug 3, 2000Paper

Estimation of the indirect effect of Haemophilus influenzae type b conjugate vaccine in an American Indian population

International Journal of Epidemiology
Lawrence H MoultonMathuram Santosham

Abstract

Oropharyngeal carriage studies of Haemophilus influenzae type b (Hib) and the rapid drop in Hib invasive disease in countries with widespread Hib conjugate vaccine immunization programmes for infants have indicated there may be significant indirect effects (herd immunity) associated with these vaccines. Our goal was to quantify the magnitude of these effects in an American Indian population during its early years of Hib immunization. In a synthetic case-cohort study, we combined data from an efficacy trial, an immunization uptake records survey, and ongoing surveillance for Hib disease on the Navajo Nation from 1988 to 1992. Decline in the incidence of invasive Hib disease among children <2 years old was estimated via proportional hazards survival models as a function of individual immunization status and the proportion of immunized children in a community. The predominant vaccine during the study period was Hib-OMPC (92% of immunizations). The effectiveness of receipt of at least one dose was 97.2%. Compared to communities with 0-20% coverage with at least one dose, residence in communities with 20-40% and 40-60% coverage was associated with risk reductions of 56.5% and 73.2%, respectively. The results indicate substantial ind...Continue Reading

References

Feb 25, 1991·American Journal of Epidemiology·M E HalloranC J Struchiner
Nov 1, 1995·American Journal of Epidemiology·L H MoultonM Santosham
Jan 1, 1995·The Journal of Infectious Diseases·M L BarbourE R Moxon
Feb 3, 1998·International Journal of Epidemiology·L H Moulton, M J Dibley

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Citations

Aug 10, 2006·JAMA : the Journal of the American Medical Association·Karen D CowgillJ Anthony G Scott
Apr 23, 2003·Vaccine·Katherine L O'Brien, Ron Dagan
Sep 10, 2005·Nature Biotechnology·Nils Lonberg
Aug 9, 2006·Journal of Biopharmaceutical Statistics·L H MoultonG R Siber
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eugene V MillarMathuram Santosham
Jul 28, 2009·The Pediatric Infectious Disease Journal·Valsan Philip VergheseMark C Steinhoff
Feb 26, 2008·Bulletin of the World Health Organization·F E AndreH J Schmitt
Feb 9, 2008·Emerging Infectious Diseases·Michael G BruceAlan J Parkinson
Aug 22, 2001·Controlled Clinical Trials·L H MoultonM Santosham
Aug 7, 2003·Expert Review of Vaccines·P Helena Mäkelä, Helena Käyhty
Sep 15, 2009·Lancet·James P WattUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Jul 18, 2015·Human Vaccines & Immunotherapeutics·Carla D Scarbrough LefebvreBaudouin Standaert
Oct 31, 2006·Vaccine·Mathuram SantoshamKatherine L O'Brien
Apr 29, 2015·Vaccine·Bradford D GessnerImran Khan
Aug 21, 2013·Human Vaccines & Immunotherapeutics·Michael E Pichichero
Jan 28, 2015·Emerging Infectious Diseases·Eli B NixMarina Ulanova
Apr 30, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Gail L Rodgers, Keith P Klugman
Dec 24, 2005·Expert Review of Vaccines·Aruna ChandranMathuram Santosham
Feb 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Evan J AndersonRam Yogev
Oct 13, 2009·The Cochrane Database of Systematic Reviews·George H SwinglerGregory Gd Hussey
Dec 22, 2006·Expert Review of Vaccines·Helena KäyhtyHelena Mäkelä
May 23, 2020·Vaccines·Vicente Javier Clemente-SuárezJose Francisco Tornero-Aguilera
Sep 9, 2017·Tropical Diseases, Travel Medicine and Vaccines·Rotem Lapidot, Christopher J Gill

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