PMID: 9438065Jan 23, 1998Paper

Estimation of the numerical densities of neurons and synapses in cerebral cortex

Brain Research. Brain Research Protocols
T MikiYoshiki Takeuchi

Abstract

In this paper we discuss a stereological technique, 'the unfolding method', for a quantitative study of the nervous system [1,31]. Stereology implies a geometric analysis of structures and textures, and is a method to derive directly metric properties of structures from two-dimensional sections on the basis of geometrico-statistical reasoning [36,37]. Recent advances in the stereological method allow quantitative analysis [8,19,27,32]. Images on sections provide only two-dimensional information, but the stereological method can offer three-dimensional and quantitative information [19]. The need for quantitative analysis is more important and useful in the central nervous system (CNS) than in other organs. Two functional units, neurons and synapses, are of particular interest in evaluating CNS function. Numerical densities of neurons and synapses in rat visual cortex were estimated using the unfolding method at light and electron microscopic levels, respectively. Once the numerical densities of neurons and synapses were obtained, synapse-to-neuron ratios could be calculated. The ratios are interpreted as a means to obtain an index of interneuronal connectivity [9]. The unfolding method may become a powerful strategy in neuroscie...Continue Reading

References

Oct 1, 1986·Journal of Neuroscience Methods·H Braendgaard, H J Gundersen
Mar 1, 1987·Cell and Tissue Research·R K Calverley, D G Jones
Jan 1, 1987·Experimental Brain Research·M W Miller
Jan 1, 1972·Brain : a Journal of Neurology·B G Cragg
Oct 14, 1994·Brain Research. Developmental Brain Research·T MikiY Takeuchi

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Citations

Oct 24, 2001·Brain Research. Brain Research Protocols·P S ManoonkitiwongsaP D Lyden
Jun 19, 2003·The Journal of Physiology·Carl HolmgrenYuri Zilberter
Mar 13, 2013·Brain Structure & Function·Pablo HennyJ Paul Bolam
Jun 22, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Takanori MikiYoshiki Takeuchi
Jul 25, 2006·Neural Networks : the Official Journal of the International Neural Network Society·Christopher Johansson, Anders Lansner
Dec 5, 2014·PLoS Computational Biology·Roman BauerRodney J Douglas
Jun 8, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Panya S ManoonkitiwongsaPatrick D Lyden

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