Estimation of the optimum number and location of nanoparticle injections and the specific loss power for ideal hyperthermia

Journal of Thermal Biology
Mostafa Pasandi BoroonSajad Razavi Bazaz

Abstract

Hyperthermia is one of the most appealing methods of cancer treatment in which the temperature of tumor is elevated to reach a desired temperature. One of the methods of increasing tissue temperature is injection of nanoparticle fluids to tumor and applying alternative magnetic field, which is called magnetic nanoparticle hyperthermia method. The total number of injection points, as well as the their location within a tissue play a significant role in this method. Furthermore, the power of heating of a magnetic material per gram or specific loss power (SLP) is another important factor which needs to be investigated. As the uniform temperature of 43 °C is effective enough for a tumor regression in certain specific tissues, the inverse method is applied to find out both the number of injection points and their location. Furthermore, the effective amount of heat generated by nanoparticles is investigated by this technique. Two-dimensional cancerous brain tissue was considered, zero gradients on boundary conditions were assumed, and diffusion equation and Pennes equation, which is regarded as energy equation, were solved, respectively. Conjugate gradient technique as a one way of inverse methods is applied, and unknowns are investi...Continue Reading

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