Estimation of the percolation thresholds in lobenzarit disodium native dextran matrix tablets

AAPS PharmSciTech
Eddy Castellanos GilI Caraballo

Abstract

The objective of the present work is to estimate for the first time the percolation threshold of a new series of dextran (native dextran of high molecular weight [B110-1-2, Mw = 2 x 10(6)]), in matrices of lobenzarit disodium (LBD) and to apply the obtained result to the design of hydrophilic matrices for the controlled delivery of this drug. The formulations studied were prepared with different amounts of excipient in the range of 20% to 70% wt/wt. Dissolution studies were performed using the paddle method (100 rpm) and one face water uptake measurements were performed using a modified Enslin apparatus. The Higuchi, zero-order, and Hixson-Crowell models as well as the nonlinear regression model were employed as empiric methods to study the release data. Values of diffusion exponent 0.563 < n < 0.786 (Korsmeyer equation) for dissolution profile and water uptake mechanism 0.715 < n < 1 (Davidson and Peppas equation) suggested anomalous or complex mechanisms. On the other hand, the contribution of the relaxation or erosion and of the diffusive mechanism in Peppas-Sahlin equation indicated that the main mechanism for drug delivery from tablets is swelling controlled delivery (K(r)/K(d) < 1). The critical points observed in kinetic...Continue Reading

References

Aug 1, 2000·International Journal of Pharmaceutics·C FerreroM R Jiménez-Castellanos
Feb 24, 2005·International Journal of Pharmaceutics·Shahla JamzadReza Fassihi
Feb 1, 2006·International Journal of Pharmaceutics·Antonia MirandaIsidoro Caraballo
Apr 6, 2006·International Journal of Pharmaceutics·Eddy Castellanos GilJyrki Heinämäki
May 3, 2006·Chemical & Pharmaceutical Bulletin·Antonia MirandaIsidoro Caraballo
Aug 1, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Inmaculada FuertesIsidoro Caraballo
Nov 4, 2006·Advanced Drug Delivery Reviews·Chien-Chi Lin, Andrew T Metters
Mar 27, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tommasina CovielloFranco Alhaique
Jun 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eddy Castellanos GilBernard Bataille

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Citations

Aug 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Eddy Castellanos GilIsidoro Caraballo
Nov 4, 2017·AAPS PharmSciTech·Cosima HirschbergMiriam Pein-Hackelbusch

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