Estimation of the synthetic routes of seized methamphetamines using GC-MS and multivariate analysis

Forensic Science International : Synergy
Sanggil ChoeSuncheun Kim

Abstract

One hundred and twenty six seized methamphetamine (MA) samples were analyzed using GC-MS. All the peaks that appeared in the chromatograms were investigated and 61 impurities including n-octacosane (internal standard) were identified. Among them, 37 impurities were already known or newly identified by comparing with commercial library entries and 18 impurities were detected for the first time. To estimate the synthetic routes of MA samples, route specific impurities had to be selected for each method. Two naphthalenes, 1,3-dimethyl-2-phenylnaphthalene and 1-benzyl-3-methylnaphthalene were selected as Nagai route specific impurities and three diasteromers, UK-19.62(58_165_178) I, UK-19.95(58_165_178) II, UK-20.49(58_165_178) III were also selected not only for their high frequency detection only in Nagai samples but also for the high principal component analysis (PCA) correlation values. For the Emde route, N,N-dimethyl-3,4-diphenylhexane-2,5-diamine and N-methyl-1-{4-[2-(methylamino)propyl]phenyl}-1-phenylpropan-2-amine were selected as route specific impurities, and N,N-di(β-phenylisopropyl)amine I (DPIA I), N,N-di(β-phenylisopropyl)amine II (DPIA II), N,N-di(β-phenylisopropyl)methylamine I (DPIMA I) and N,N-di(β-phenylisoprop...Continue Reading

References

Mar 5, 2002·Journal of Chromatography. a·Yukiko MakinoTetsuo Nagano
Aug 2, 2003·Forensic Science International : Synergy·Hiroyuki InoueTohru Kishi
Oct 6, 2005·Forensic Science International : Synergy·Tetsuro Sasaki, Yukiko Makino
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Jul 17, 2007·Forensic Science International : Synergy·Beom Jun KoSung-Hong Kim
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Apr 14, 2010·Journal of Forensic Sciences·Helen SalourosStephen Davies
Nov 7, 2012·Forensic Science International : Synergy·Sanggil ChoeSuncheun Kim

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Citations

Feb 1, 2017·Journal of Separation Science·Nafiseh ShekariKourosh Tabar Heidar
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Aug 7, 2021·Drug Testing and Analysis·Deanna LangoneK Paul Kirkbride

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