Abstract
One hundred and twenty six seized methamphetamine (MA) samples were analyzed using GC-MS. All the peaks that appeared in the chromatograms were investigated and 61 impurities including n-octacosane (internal standard) were identified. Among them, 37 impurities were already known or newly identified by comparing with commercial library entries and 18 impurities were detected for the first time. To estimate the synthetic routes of MA samples, route specific impurities had to be selected for each method. Two naphthalenes, 1,3-dimethyl-2-phenylnaphthalene and 1-benzyl-3-methylnaphthalene were selected as Nagai route specific impurities and three diasteromers, UK-19.62(58_165_178) I, UK-19.95(58_165_178) II, UK-20.49(58_165_178) III were also selected not only for their high frequency detection only in Nagai samples but also for the high principal component analysis (PCA) correlation values. For the Emde route, N,N-dimethyl-3,4-diphenylhexane-2,5-diamine and N-methyl-1-{4-[2-(methylamino)propyl]phenyl}-1-phenylpropan-2-amine were selected as route specific impurities, and N,N-di(β-phenylisopropyl)amine I (DPIA I), N,N-di(β-phenylisopropyl)amine II (DPIA II), N,N-di(β-phenylisopropyl)methylamine I (DPIMA I) and N,N-di(β-phenylisoprop...Continue Reading
References
Mar 1, 1983·Headache·W K Amery
Sep 1, 1984·British Journal of Pharmacology·O FagbemiA L Rothaul
Mar 5, 2002·Journal of Chromatography. a·Yukiko MakinoTetsuo Nagano
Aug 2, 2003·Forensic Science International : Synergy·Hiroyuki InoueTohru Kishi
Mar 8, 2005·Forensic Science International : Synergy·Laura AalbergErkki Sippola
Sep 29, 2005·Forensic Science International : Synergy·Kenji KuwayamaTohru Kishi
Oct 6, 2005·Forensic Science International : Synergy·Tetsuro Sasaki, Yukiko Makino
Mar 22, 2006·Forensic Science International : Synergy·Ying QiAdam McCluskey
Aug 1, 2006·Forensic Science International : Synergy·Jae Sin LeeJeong Hill Park
Oct 24, 2006·Forensic Science International : Synergy·Kenji KuwayamaTohru Kishi
Dec 6, 2006·Forensic Science International : Synergy·Ying QiAdam McCluskey
Dec 26, 2006·Forensic Science International : Synergy·Jae Sin LeeJeong Hill Park
Jun 15, 2007·Forensic Science International : Synergy·Kenji KuwayamaTohru Kishi
Jul 17, 2007·Forensic Science International : Synergy·Beom Jun KoSung-Hong Kim
Jun 10, 2008·Analytica Chimica Acta·Jae Sin LeeJeong Hill Park
Jul 30, 2009·Analytical Chemistry·Vanitha KunalanAllan R McPherson
Apr 14, 2010·Journal of Forensic Sciences·Helen SalourosStephen Davies
Nov 7, 2012·Forensic Science International : Synergy·Sanggil ChoeSuncheun Kim
Citations
Aug 16, 2016·Forensic Science International : Synergy·Tai-Hung ChenShu-Pao Wu
Feb 1, 2017·Journal of Separation Science·Nafiseh ShekariKourosh Tabar Heidar
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Aug 7, 2021·Drug Testing and Analysis·Deanna LangoneK Paul Kirkbride