Estimation of tumor volume in radical prostatectomy specimens in routine clinical practice

American Journal of Clinical Pathology
A A RenshawA V D'Amico

Abstract

Tumor volume may be an independent prognostic factor in prostatic adenocarcinoma but is too difficult, expensive, and time consuming to measure in routine clinical practice. We sought to evaluate several simple estimates of tumor volume in radical prostatectomy specimens. Specimens from 86 radical prostatectomies were completely sectioned, and the true tumor was volume calculated using a computer-assisted image analysis technique. True tumor volume was then compared with the results of several estimation techniques. True tumor volume ranged from 0.004 to 9.74 cc (mean, 1.59 cc). The Pearson correlation coefficient of the length of the maximum dimension of tumor as measured from the slide with true tumor volume had an r2 of 0.688. However, 15 (75%) of 20 tumors less than 0.5 cc had a single maximum diameter of less than 10 mm, and only 3 (4%) of 66 tumors with volumes greater than 0.5 cc had a maximum diameter of less than 10 mm. Fifteen (68%) of 22 tumors with true tumor volumes greater than 2 cc had a maximum dimension greater than 20 mm, and only 2 (3%) of 64 tumors with volumes less than 2 cc had a maximum dimension greater than 20 mm. Increasing correlation with true tumor volume could be obtained from the largest single tu...Continue Reading

Citations

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