Estimation of urea distribution volume in hemodialysis patients

Néphrologie & thérapeutique
Afef KoubaaThierry Petitclerc

Abstract

On-line urea clearance estimation, currently available on some dialysis monitors, makes it possible to calculate the dialysis dose Kt and thus allows to estimate Kt/V for each session, providing an estimation of urea distribution volume (V) at equilibrium assumed equal to total body water. Three methods suitable for routinely estimating V, using the anthropometric Watson formula (V(Wat)), the body composition monitor (BCM) device (Fresenius Medical Care) based on bio-impedance analysis (V(imp)) and the indirect estimation (V(Daug)) obtained from measurement of Kt/(Kt/V)(sp) ratio respectively are compared during 25 dialysis sessions in 15 patients to a direct estimation (V(DDQ)) obtained by direct quantification of dialysis (DDQ) considered as the gold standard in hemodialysis patient.. V(Watson) overestimates V(DDQ) by about 20%. The values of V(imp) (29.1±5.6 L) and V(Daug) (29.5±4.6 L) are in agreement with V(DDQ) (29.9±5.2 L). Correlation coefficient with V(DDQ) is better for V(imp) (r=0.94) than for V(Daug) (r=0.85). Bio-impedancemetry using BCM and indirect method using the second generation Daugirdas equation are two methods of clinical interest for estimating V. Bio-impedancemetry does not require blood sample, but it n...Continue Reading

References

Jul 1, 1992·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S Pastan, C Gassensmith
Jan 1, 1980·The American Journal of Clinical Nutrition·P E WatsonR D Batt
Nov 1, 1993·Journal of the American Society of Nephrology : JASN·J T Daugirdas
Aug 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J T Daugirdas
Oct 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C ManzoniF Locatelli
Mar 9, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D SchneditzN W Levin
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert F Kushner, David M Roxe
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kenneth Scott BrimbleEuan J Carlisle
Nov 25, 2003·Kidney International·Andreas WuepperLorraine Edwards
Jun 3, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Francis Dumler
Jul 16, 2004·Kidney International·Salvatore Di FilippoFrancesco Locatelli
Aug 14, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elizabeth J LindleyEric J Will

❮ Previous
Next ❯

Citations

May 28, 2013·BMC Nephrology·Steven GrangéMichel Godin
Jan 18, 2013·Indian Journal of Nephrology·A AlayoudZ Oualim
Jun 11, 2011·International Journal of Nephrology·Fischbach MichelSchmitt Claus Peter
Jan 13, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ariane ZaloszycClaus Peter Schmitt
Jun 24, 2010·Néphrologie & thérapeutique·Alain FicheuxAngel Argilés
Mar 19, 2013·The International Journal of Artificial Organs·Caroline CréputThierry Petitclerc
Feb 3, 2021·Seminars in Dialysis·Thierry Petitclerc, Christophe Ridel
Apr 15, 2019·Néphrologie & thérapeutique·Mélanie HanoyDominique Guerrot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Elizabeth J LindleyE Will
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Alain FicheuxAngel Argilés
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Francisco MaduellJosep M Campistol
© 2021 Meta ULC. All rights reserved