Estivation-responsive microRNAs in a hypometabolic terrestrial snail

PeerJ
Myriam P HoyeckKenneth B Storey

Abstract

When faced with extreme environmental conditions, the milk snail (Otala lactea) enters a state of dormancy known as estivation. This is characterized by a strong reduction in metabolic rate to <30% of normal resting rate that is facilitated by various behavioural, physiological, and molecular mechanisms. Herein, we investigated the regulation of microRNA in the induction of estivation. Changes in the expression levels of 75 highly conserved microRNAs were analysed in snail foot muscle, of which 26 were significantly upregulated during estivation compared with controls. These estivation-responsive microRNAs were linked to cell functions that are crucial for long-term survival in a hypometabolic state including anti-apoptosis, cell-cycle arrest, and maintenance of muscle functionality. Several of the microRNA responses by snail foot muscle also characterize hypometabolism in other species and support the existence of a conserved suite of miRNA responses that regulate environmental stress responsive metabolic rate depression across phylogeny.

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Citations

Dec 12, 2020·Journal of Cellular Physiology·Hanane Hadj-MoussaKenneth B Storey
Nov 30, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Liam J Hawkins, Kenneth B Storey
Oct 11, 2020·Ecotoxicology and Environmental Safety·Haitham G Abo-Al-Ela, Caterina Faggio
Nov 20, 2021·The Journal of Experimental Biology·Alexandra StaikouBasile Michaelidis

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Methods Mentioned

BETA
PCR

Software Mentioned

BLASTn
CLUSTAL OMEGA

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