Estradiol-17 beta affects estrogen receptor distribution and elevates progesterone receptor content in baboon aorta

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
A L LinS A Shain

Abstract

We used the synthetic estrogen R2858 (moxestrol) and estradiol-17 beta, respectively, to characterize the estrogen receptor in baboon (Papio sp.) aortic or myocardial cytoplasmic and nuclear preparations. We observed regional differences in the cytoplasmic fraction estrogen and progesterone receptor content of aortic arch, thoracic aorta, and abdominal aorta when tissues from either oophorectomized or oophorectomized estradiol-17 beta-treated subjects were compared. The estrogen receptor content was highest in the abdominal aorta and lowest in the aortic arch. In contrast, the cytoplasmic fraction progesterone receptor content was highest in the aortic arch and lowest in the abdominal aorta. The nuclear fraction estrogen receptor could not be demonstrated in preparations from cardiovasculature of oophorectomized female baboons. The use of Silastic implants to administer a physiologic concentration of estradiol-17 beta to oophorectomized female baboons caused a 20% to 50% reduction in cytoplasmic fraction estrogen receptor content, which was quantitatively accounted for by the appearance of estrogen receptor in the corresponding nuclear aortic or myocardial preparation. Estrogen administration caused a 20% to 40% increase in cyt...Continue Reading

References

Oct 1, 1976·Annals of Internal Medicine·W B KannelT Gordon
Nov 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A L LinS A Shain
Nov 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A L Lin, S A Shain
Oct 8, 1983·Lancet·W H Price, J F Clayton
Jan 1, 1983·Epidemiologic Reviews·S JohanssonC Wilhelmsson
Jan 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B ZumoffD K Fukushima
May 1, 1983·The American Journal of Medicine·G B PhillipsP M McNamara
Jan 1, 1982·Archives of Internal Medicine·M H LuriaR G Wieland
Dec 1, 1982·The American Journal of Medicine·E L KlaiberJ E Dalen

❮ Previous
Next ❯

Citations

Dec 29, 1995·European Journal of Pharmacology·T NakajimaY Kurachi
Oct 1, 1996·Thrombosis Research·G F GensiniR Abbate
Aug 1, 1992·Journal of the American College of Cardiology·J K WilliamsT B Clarkson
May 1, 1994·Neurotoxicology and Teratology·J C Glantz, J R Woods
Sep 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·A L LinS A Shain
Mar 18, 2005·International Journal of Cardiology·Rute Loreto S OliveiraJosé Antônio F Ramires
Sep 9, 1999·European Journal of Pharmacology·H Teoh, R Y Man
Aug 14, 2001·Molecular and Cellular Endocrinology·E AavikP Hayry
Nov 15, 1996·Journal of the American College of Cardiology·E A KarpanouP K Toutouzas
Nov 11, 1998·Journal of the American College of Cardiology·R J McCredieD S Celermajer
Feb 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·H MurakamiH Sasano
Sep 23, 2009·Menopause : the Journal of the North American Menopause Society·Andrew SherwoodJudith McFetridge-Durdle
Mar 4, 2005·Clinical and Experimental Pharmacology & Physiology·Rosa A Bobadilla LPedro López-Sanchez
Jul 1, 1993·British Journal of Pharmacology·R VargasP W Ramwell
Jun 27, 1998·The Journal of Pharmacy and Pharmacology·D Otter, C Austin
Dec 22, 2006·Journal of Cardiothoracic Surgery·Gianluca PolvaniPaolo Biglioli
May 10, 2005·European Journal of Endocrinology·E Diamanti-KandarakisM Mavrikakis
Aug 13, 2009·Climacteric : the Journal of the International Menopause Society·M A DuzenliM Tokac
Feb 13, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Derya KocerHalit Diri
Jun 19, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fahri BayramSabahattin Muhtaroglu
Mar 1, 2012·The Journal of Headache and Pain·Simona SaccoAntonio Carolei
Dec 10, 1999·Cardiology Clinics·P Toutouzas
Jun 1, 1997·American Journal of Obstetrics and Gynecology·R ChelskyG D Giraud
Jun 1, 1996·American Journal of Obstetrics and Gynecology·G D GiraudL Speroff
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M R AdamsT B Clarkson
Jul 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M R AdamsT B Clarkson
May 1, 1990·Circulation·J K WilliamsH S Klopfenstein
May 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·M R AdamsJ R Kaplan
Oct 30, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Mehmet Akif DüzenliMehmet Tokac

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.