Estradiol acts locally within the retrochiasmatic area to inhibit pulsatile luteinizing-hormone release in the female sheep during anestrus

Biology of Reproduction
J Gallegos-SanchezJ C Thiéry

Abstract

In the present study we have identified a site of action of estradiol in the inhibition of LH secretion during anestrus in the ewe. In the first experiment, we studied six sites: the medial preoptic area, the lateral preoptic area, the ventromedial hypothalamus, the ventrolateral hypothalamus, the retrochiasmatic area (RCh), and the periventricular posterior hypothalamus. We compared the changes in parameters of pulsatile LH secretion (interpulse interval, mean nadir, mean amplitude, and mean area under curve) during three 6-h sampling periods: before and 30-36 h and 9 days after intracerebral implantation of crystalline estradiol. Animals that received estradiol in the RCh (n = 5) showed a significantly greater increase in both the intervals between pulses of LH (up 116%, p < 0.03) and the area under the curve (up 180%, p < 0.01) than any of the other groups of 7 animals. In the second experiment, implantation of estradiol in the RCh (n = 6) induced an increase in the intervals between pulses of LH (p < 0.03), whereas receiving an empty implant (n = 6) had no effect, showing that estradiol specifically induced increases in the intervals between pulses. Thus, estradiol appears to act in the RCh where the dopaminergic A15 nucleu...Continue Reading

Citations

Jun 14, 2000·Animal Reproduction Science·C J ScottI J Clarke
Jun 14, 2000·Animal Reproduction Science·N Parvizi
Jul 27, 2002·Domestic Animal Endocrinology·J C ThiéryB Malpaux
Aug 31, 2014·General and Comparative Endocrinology·Guangfu HuAnderson O L Wong
Mar 3, 2004·Annals of the New York Academy of Sciences·Jean-Claude Thiery, Benoit Malpaux
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·P ChemineauB Malpaux
Sep 1, 2010·Reproduction in Domestic Animals = Zuchthygiene·P ChemineauB Malpaux
Jun 9, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Casey C NestorRobert L Goodman

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