Estradiol and cortisol interactions in youth externalizing psychopathology

Psychoneuroendocrinology
Jennifer L TackettRobert A Josephs

Abstract

Growing evidence has indicated that gonadal and stress hormones interact to shape socially dominant behavior and externalizing psychopathology; however, such work to date has focused exclusively on the testosterone-cortisol interaction, despite expectations that estradiol should be associated with similar behavioral outcomes to testosterone. Here, we present the first empirical test of the hypothesis that adolescent males and females (N=105, ages 13-18) with high estradiol and low cortisol concentrations are at highest risk for externalizing problems, but - replicating previous work - only among adolescents high on pathological personality traits. Parents reported on youth psychopathology and personality, and hormone concentrations were measured via passive drool. Results confirmed the hypothesis: high estradiol was associated with more externalizing behaviors, but only when cortisol was low and personality traits of disagreeableness and emotional instability were high. Further, these associations held when controlling for testosterone concentrations. These findings provide the first empirical evidence of a hypothalamic pituitary adrenal (HPA)×hypothalamic pituitary gonadal (HPG) axis interaction that extends the "dual hormone"...Continue Reading

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Nov 23, 2013·Journal of Adolescence·Jennifer L TackettCarla Sharp
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Jun 17, 2014·Personality Disorders·Jennifer L TackettRobert A Josephs
Jul 9, 2014·Psychoneuroendocrinology·Deidra BedgoodBulent Turan
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Citations

Jul 31, 2016·Psychoneuroendocrinology·K Paige HardenMichaela Riediger
Oct 11, 2016·Developmental Cognitive Neuroscience·Ahna Ballonoff SuleimanRonald E Dahl
Mar 10, 2017·Evolutionary Psychology : an International Journal of Evolutionary Approaches to Psychology and Behavior·Efrat BarelOrna Tzischinsky
May 21, 2017·Hormones and Behavior·Kathleen V Casto, Smrithi Prasad
Feb 2, 2020·International Journal of Behavioral Medicine·Jenna K RiederMariann R Weierich
Nov 13, 2020·Current Psychiatry Reports·Katja BertschSabine C Herpertz
Mar 7, 2020·Behavior Therapy·Theodore P Beauchaine, Jennifer L Tackett
Jun 17, 2020·Psychoneuroendocrinology·Adi LausenAnnekathrin Schacht
Aug 11, 2021·Journal of Affective Disorders·Briana Nc ChronisterJose R Suarez-Lopez

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