Estradiol and dehydroepiandrosterone potentiate levodopa-induced locomotor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys

Endocrine
Nancy BélangerThérèse Di Paolo

Abstract

Six monkeys were rendered hemiparkinsonian with a unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These monkeys displayed ipsilateral circling under basal conditions, and after dopaminergic stimulation with levodopa they decreased their ipsilateral circling and started turning to the contralateral side of their lesion. The effect of 17beta-estradiol and dehydroepiandrosterone (DHEA) was investigated in these animals. 17beta-Estradiol (0.1 mg/kg) added to a threshold dose of levodopa significantly potentiated contralateral circling (mean/30 min) compared to saline or threshold levodopa treatment whereas the duration of circling remained unchanged. DHEA (1-15 mg/kg) alone induced contralateral circling, compared to saline treatment, for 90 min. In addition, DHEA (1-15 mg/kg) potentiated the contralateral circling (mean/30 min) induced by a threshold dose of levodopa and did not change the duration of levodopa circling. A maximal response was observed with 1 or 5 mg/kg of DHEA combined with levodopa depending on the monkey. No correlation was found between the dose for the maximal DHEA response and baseline circling or threshold dose of levodopa. These results suggest that 17beta-estradiol or DHEA is able to ...Continue Reading

Citations

Jan 17, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M NilssonK Dahlman-Wright
Dec 31, 2008·Journal of Neuroscience Research·Marc Morissette, Thérèse Di Paolo
Dec 29, 2006·Annals of the New York Academy of Sciences·Ioannis CharalampopoulosAchille Gravanis
Oct 29, 2005·Neurobiology of Aging·Nancy BélangerThérèse Di Paolo
Feb 9, 2012·Journal of Korean Academy of Nursing·Myoung Ae ChoeSonghee Jeon
Mar 11, 2018·The Journal of Pharmacology and Experimental Therapeutics·Nicolas VeyresPhilippe Huot
Oct 23, 2009·Journal of Medicinal Chemistry·Theodora CalogeropoulouAchille Gravanis

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