Estradiol-associated variation in responses of rostral medullary neurons to somatovisceral stimulation

Experimental Neurology
C H Hubscher

Abstract

The lordosis posture and cervix stimulation during copulation are important reproductive events involving complex neural circuitries that are under hormonal influence. An important component of this circuitry, neurons within the medullary reticular formation (MRF), was examined in the present study using electrophysiological techniques. Single unit extracellular recordings were performed in the MRF of 27 urethane-anesthetized female rats. Using bilateral electrical stimulation of the dorsal nerve of the clitoris as the search stimulus, a detailed examination of the somatovisceral convergent responses of 585 individual MRF neurons was made. A total of 7 different groups of cycling and ovariectomized/hormone-supplemented rats were examined and their neuronal response properties to mechanical stimulation of various pelvic organs (cervix pressure, vaginal distension, colon distension) compared. The results indicate the existence of complex response properties as well as several variations in MRF response characteristics that are hormone-dependent. Specifically, estradiol is associated with hyposensitivity to cervix pressure and hypersensitivity to stroking the face. These opposing effects of estradiol in the same subset of neurons ...Continue Reading

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Citations

Jun 3, 2009·Behavioral Neuroscience·Sarah H Meerts, Ann S Clark
Oct 14, 2008·Hormones and Behavior·Sarah H Meerts, Ann S Clark
Oct 3, 2006·Experimental Neurology·Ezidin G Kaddumi, Charles H Hubscher
Jun 15, 2014·Journal of Manipulative and Physiological Therapeutics·William R ReedCynthia R Long
Sep 16, 2014·Journal of Manipulative and Physiological Therapeutics·William R ReedStephen M Onifer
Jan 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kyle J CothronCharles H Hubscher
Aug 9, 2013·Journal of Neurophysiology·C H HubscherT S Brink
Sep 5, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Casey J SteadmanCharles H Hubscher

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