PMID: 3350472Mar 1, 1988

Estradiol benzoate can function as an unconditioned stimulus in a conditioned taste aversion paradigm

Hormones and Behavior
J MieleB Svare

Abstract

The extent to which gonadal steroid hormones can serve as unconditioned stimuli in a conditioned taste aversion paradigm was examined in Rockland-Swiss albino mice. With saccharin serving as the conditioned stimulus, subcutaneously injected estradiol benzoate, but not progesterone or testosterone propionate, was found to be a potent unconditioned stimulus in both male and female mice. Dose-response effects were also observed; increasing dosages of estradiol benzoate led to increasingly stronger conditioned aversions in both males and females. The aversion detected in males was more resistant to extinction than that seen in females. Prepubertal gonadectomy reversed the sex-dependent effects of estradiol benzoate in learned aversions in adulthood; castration of males promoted the extinction process, whereas ovariectomy of females retarded extinction. The results may be useful for our understanding of the mechanisms involved in conditioned taste aversion learning as well as a wide array of hormone-dependent behavioral responses.

Citations

Nov 1, 1990·Physiology & Behavior·R Ganesan, J W Simpkins
Oct 1, 1991·Physiology & Behavior·R Ganesan, J W Simpkins
Feb 1, 1994·Physiology & Behavior·R Ganesan
Apr 3, 2001·Physiology & Behavior·L M Flanagan-CatoJ L King
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R de Beun
Jul 13, 2012·Cerebral Cortex·Xiao XiaoYu-Qiu Zhang
Jan 18, 2016·Developmental Cognitive Neuroscience·Elizabeth P ShulmanLaurence Steinberg
Oct 19, 2004·Physiology & Behavior·Ruth I Wood
Oct 27, 2004·Pharmacology, Biochemistry, and Behavior·Anita N DiMeo, Ruth I Wood
Jan 12, 2005·Physiology & Behavior·Houri HintiryanK C Chambers
Oct 19, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica SantolloL A Eckel

Related Concepts

Castration
Conditioned Reflex
Estradiol, (16 alpha,17 beta)-Isomer
Extinction, Psychological
Mice, Inbred Strains
Progesterone, (9 beta,10 alpha)-Isomer
Taste Perception
Sterotate

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