Estradiol enhances neurogenesis in the dentate gyri of adult male meadow voles by increasing the survival of young granule neurons

Neuroscience
B K OrmerodLiisa A M Galea

Abstract

This study investigated whether estradiol influenced the survival of new granule neurons, independent of altering cell proliferation, in the adult rodent dentate gyrus and whether estradiol-induced changes in new neuron number relate to any observed changes in hippocampus-dependent behavior. To test whether estradiol specifically promotes the survival of new neurons we injected castrated adult male meadow voles with the cell synthesis marker bromodeoxyuridine (BrdU; 50 mg/kg) twice on day 0 and then injected either estradiol (10 microg) or vehicle for 5 consecutive days either over days 1-5, days 6-10 or days 11-15 and perfused them on day 16. Estradiol doubled the number of hippocampal BrdU-labeled neurons but only when administered during a discrete period (days 6-10; P< or =0.01) when most new neurons extend their axons [J Comp Neurol 413 (1999) 146]. To test whether the estradiol-induced increase in new neuron number was related to hippocampus-dependent behavior, males were injected with BrdU twice on day 0 and with estradiol or vehicle over days 6-10 before standard Morris water maze training commenced on day 16, 5 days after the final hormone injection. As in the first study, estradiol-treated males had more BrdU-labeled ...Continue Reading

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
May 1, 1994·Trends in Neurosciences·R M LindsayP S DiStefano
Nov 1, 1994·Journal of Neurobiology·A M Davies
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Oct 23, 1997·Science·S W LambertsA J van der Lely
Apr 29, 1998·Neuroreport·L M Garcia-SeguraJ A Chowen
Oct 24, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C M Smith, M B Luskin
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D B DubalP M Wise
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Apr 30, 1999·Anatomy and Embryology·C Beyer
Aug 28, 1999·The Journal of Comparative Neurology·N B Hastings, E Gould
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Sep 7, 2000·The Journal of Comparative Neurology·T D PalmerF H Gage
Nov 1, 2000·The Prostate. Supplement·A W van den Beld, S W Lamberts
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K JinD A Greenberg
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Nov 28, 2001·The European Journal of Neuroscience·M BanasrA Daszuta
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Apr 5, 2002·Journal of Neurobiology·Christie D FowlerZuoxin Wang
Apr 12, 2002·Brain Research. Developmental Brain Research·N L Hayes, R S Nowakowski
May 23, 2002·Recent Progress in Hormone Research·Evan R Simpson, Mitch Dowsett
Nov 21, 2002·Hippocampus·Tracey J ShorsElizabeth Gould
Sep 23, 2003·Journal of Molecular Neuroscience : MN·Barbara B Sherwin

❮ Previous
Next ❯

Citations

Jan 19, 2010·Chinese Journal of Integrative Medicine·Shi-feng Chu, Jun-tian Zhang
Nov 6, 2010·Archives of Pharmacal Research·Kyung-Ok Cho, Seong Yun Kim
Oct 27, 2010·Nature Communications·Ashley W SeifertMartin J Cohn
Dec 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexandra Veyrac, Julie Bakker
Aug 12, 2010·Behavioural Pharmacology·Erika Estrada-CamarenaAlonso Fernández-Guasti
Dec 2, 2005·Annual Review of Psychology·David F Sherry
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shau-Ming WeiKaren F Berman
Jan 12, 2013·Cells, Tissues, Organs·Barbora FilováJúlius Hodosy
Feb 18, 2016·Neural Plasticity·Alessandra Aparecida MarquesGisele Pereira Dias
Apr 24, 2012·Hormones and Behavior·Nicolas DiotelElisabeth Pellegrini
Feb 2, 2010·Frontiers in Neuroendocrinology·Nicolas DiotelOlivier Kah
Jan 27, 2010·Biochimica Et Biophysica Acta·Cindy K Barha, Liisa A M Galea
Nov 3, 2009·Physiology & Behavior·Jennifer M Barker, Liisa A M Galea
Jul 1, 2015·Hormones and Behavior·Paula Duarte-GutermanLiisa A M Galea
Dec 15, 2007·Frontiers in Neuroendocrinology·Joanna L SpencerBruce S McEwen
Sep 4, 2007·Brain Research Reviews·Christie D FowlerZuoxin Wang
Mar 23, 2007·Molecular and Cellular Endocrinology·Gemma CasadesusMark A Smith
Mar 19, 2016·Frontiers in Neuroendocrinology·Rand MahmoudLiisa A M Galea
Jan 19, 2007·The European Journal of Neuroscience·Verónica Martínez-CerdeñoArnold R Kriegstein
Jan 18, 2006·Hippocampus·Liisa A M GaleaJodi L Pawluski
Dec 15, 2010·The European Journal of Neuroscience·Yann Le PageOlivier Kah
Mar 22, 2016·Frontiers in Neuroendocrinology·Maya OpendakElizabeth Gould
Jul 20, 2014·Biochimica Et Biophysica Acta·Pascal CoumailleauOlivier Kah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.