Estradiol increases urethral tone through the local inhibition of neuronal nitric oxide synthase expression

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Xavier GaméBernard Malavaud

Abstract

Estrogens are known to modulate lower urinary tract (LUT) trophicity and neuronal nitric oxide synthase (nNOS) expression in several organs. The aim of this study was to explore the effects of endogenous and supraestrus levels of 17beta-estradiol (E2) on LUT and urethral nNOS expression and function. LUT function and histology and urethral nNOS expression were studied in adult female mice subjected either to sham surgery, surgical castration, or castration plus chronic E2 supplementation (80 microg.kg(-1).day(-1), i.e., pregnancy level). The micturition pattern was profoundly altered by long-term supraestrus levels of E2 with decreased frequency paralleled by increased residual volumes higher than those of ovariectomized mice. Urethral resistance was increased twofold in E2-treated mice, with no structural changes in urethra, supporting a pure tonic mechanism. Acute nNOS inhibition by 7-nitroindazole decreased frequency and increased residual volumes in ovariectomized mice but had no additive effect on the micturition pattern of long-term supraestrus mice, showing that long-term supraestrus E2 levels and acute inhibition of nNOS activity had similar functional effects. Finally, E2 decreased urethral nNOS expression in ovariecto...Continue Reading

References

Jul 1, 1984·The American Journal of Physiology·K A CarlbergM Fahey
Jul 15, 1980·American Journal of Obstetrics and Gynecology·S IosifU Ulmsten
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R ElhageF Bayard
Feb 24, 1998·European Journal of Pharmacology·W TakahashiS Ueda
Apr 11, 2001·International Urogynecology Journal and Pelvic Floor Dysfunction·L CardozoH de Koning Gans
Sep 25, 2001·International Urogynecology Journal and Pelvic Floor Dysfunction·A Hextall, L Cardozo
Jun 18, 2003·Urology·Mamas A MamasAlison F Brading
Oct 11, 2003·Urology·Dudley Robinson, Linda D Cardozo
Oct 30, 2003·The Cochrane Database of Systematic Reviews·J SucklingR Kennedy
Sep 30, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Linda CardozoEboo Versi
Oct 13, 2004·European Journal of Endocrinology·Ulrike I L ModderSundeep Khosla
Feb 25, 2005·JAMA : the Journal of the American Medical Association·Susan L HendrixS Gene McNeeley
Aug 9, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rhonda L StelckLaura S Van Winkle
Jan 5, 2006·Climacteric : the Journal of the International Menopause Society·P Albertazzi, S Sharma
Jan 10, 2006·Lancet·Peggy Norton, Linda Brubaker
May 12, 2006·Neurourology and Urodynamics·Alpha Dian-Yu LinAnita Mannikarottu
Oct 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liliya M YamaleyevaMark C Chappell

❮ Previous
Next ❯

Citations

Sep 10, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X GaméB Malavaud
Jun 4, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X GaméB Malavaud
Dec 8, 2011·The Journal of Sexual Medicine·Xavier GaméBernard Malavaud
Mar 18, 2011·Neurourology and Urodynamics·Fabíola Z MónicaEdson Antunes
Feb 16, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T BenoitX Game
Oct 3, 2014·PloS One·Yung-Hsiang ChenHuey-Yi Chen
Mar 30, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Huey-Yi ChenYung-Hsiang Chen
Dec 1, 2010·Einstein·Carlos Arturo Levi D'AnconaEdson Antunes
Jan 30, 2009·Veterinary Pathology·G GakharT A Nguyen
Feb 16, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tomohiro AokiSusumu Miyamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.