Estradiol-induced conditioned taste aversion and place aversion in rats: sex- and dose-dependent effects

Physiology & Behavior
R De BeunN E Van de Poll


Effects of various doses (0-250 micrograms/kg, SC) of estradiol-17 beta (E2) in a two-bottle choice conditioned taste aversion and a two-compartment conditioned place preference procedure were studied in male and female rats. Dose-dependent taste aversion and place aversion effects of E2 were established, and the conditioned taste aversion procedure was found to be more sensitive in detecting aversive properties of E2 than the conditioned place preference procedure. Although aversive properties of E2 were found in both sexes, the effects were clearly more prominent in males as compared to females. From this study, it was concluded that E2 acts as an unconditioned aversive stimulus in both male and female rats capable of gaining control over different types of behavior by associative learning.


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Related Concepts

Association Learning
Avoidance Learning
Conditioned Reflex
Dose-Response Relationship, Drug
August Rats
Social Ecology
Taste Perception
Rats, Laboratory

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