Estradiol-induced enhancement of fear extinction in female rats: The role of NMDA receptor activation

Progress in Neuro-psychopharmacology & Biological Psychiatry
B M Graham, Elliot Scott

Abstract

Converging cross-species evidence indicates that fear extinction (the laboratory basis of exposure therapy for anxiety disorders) in females is modulated by endogenous and exogenous estradiol. The mechanisms underlying estradiol's influences on fear extinction are largely undefined. However, one likely candidate is the NMDA-receptor (NMDAr), activation of which is necessary for estradiol-mediated enhancements in structural and functional neural plasticity, as well as extinction consolidation in males. Here, we demonstrate that systemic co-administration of the non-competitive NMDAr antagonist, MK801, blocked the enhancement of fear extinction by systemic estradiol in ovariectomized rats. In intact rats, MK801 during diestrus (rising estradiol) prevented the enhancement in extinction recall in rats that received extinction training during proestrus (peak estradiol). Systemic administration of the partial NMDAr agonist D-cycloserine (DCS) prior to extinction training facilitated extinction in ovariectomized rats, mimicking the effects of estradiol. In intact rats, DCS administered on the afternoon of proestrus and the morning of estrus (declining estradiol) facilitated extinction in rats that received extinction training during m...Continue Reading

References

Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·R BiM Baudry
Jan 31, 2004·The European Journal of Neuroscience·T J ShorsB Leuner
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Lori L McMahon
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Lori L McMahon
Sep 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Deepak P SrivastavaPeter Penzes
Apr 1, 2009·Behavioral Neuroscience·Wan Yee Macy Chan, Gavan P McNally
Jun 30, 2009·Neurobiology of Learning and Memory·Julia M Langton, Rick Richardson
Mar 29, 2011·Journal of Psychiatric Research·Carmen P McLeanStefan G Hofmann
Aug 26, 2011·The American Journal of Psychiatry·Bronwyn M Graham, Mohammed R Milad
Apr 25, 2012·Behavioural Brain Research·Natalia Gindri FiorenzaJociane C Myskiw
Jun 29, 2012·Biology of Mood & Anxiety Disorders·Kelimer Lebron-Milad, Mohammed R Milad
Nov 20, 2012·Biological Psychiatry·Bronwyn M Graham, Mohammed R Milad
Mar 13, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Galvin, Ipe Ninan
May 28, 2014·Behaviour Research and Therapy·Michelle G CraskeBram Vervliet
Mar 23, 2015·Biological Psychiatry·Ebony M GloverSeth Davin Norrholm
May 12, 2015·Hormones and Behavior·Karyn M Frick
Jul 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bronwyn M Graham, Melissa Daher
Oct 26, 2016·Translational Psychiatry·J S Milligan-Saville, B M Graham

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Citations

Oct 22, 2019·The European Journal of Neuroscience·Harriet L L Day, Carl W Stevenson
Sep 13, 2019·Neurobiology of Learning and Memory·Samantha Tang, Bronwyn M Graham
Jan 26, 2020·Hormones and Behavior·Samantha Tang, Bronwyn M Graham

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