Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Rong-Yi ChenZongbing You

Abstract

The symptoms of vaginal candidiasis exacerbate in the second half of the menstrual cycle in premenopausal women when the serum estradiol level is elevated. Estradiol has been shown to inhibit Th17 differentiation and production of antifungal IL-17 cytokines. However, little is known about the mechanisms. In the present study, we used mouse splenocytes and found that estradiol inhibited Th17 differentiation through downregulation of Rorγt mRNA and protein expression. Estradiol activated estrogen receptor (ER)α to recruit repressor of estrogen receptor activity (REA) and form the ERα/REA complex. This complex bound to three estrogen response element (ERE) half-sites on the Rorγt promoter region to suppress Rorγt expression. Estradiol induced Rea mRNA and protein expression in mouse splenocytes. Using Rea small interfering RNA to knock down Rea expression enhanced Rorγt expression and Th17 differentiation. Alternatively, histone deacetylase 1 and 2 bound to the three ERE half-sites, independent of estradiol. Histone deacetylase inhibitor MS-275 dose- and time-dependently increased Rorγt expression and subsequently enhanced Th17 differentiation. In 15 healthy premenopausal women, high serum estradiol levels are correlated with low ...Continue Reading

References

Oct 29, 1998·The Journal of Biological Chemistry·M D DriscollR A Bambara
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·A SaitoO Nakanishi
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·H HoshinoA Lindén
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·M M MontanoB S Katzenellenbogen
Jul 14, 2001·Nucleic Acids Research·C M Klinge
Nov 6, 2002·The Journal of Biological Chemistry·Sudeepta AggarwalAustin L Gurney
Apr 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michelle S JansenDonald P McDonnell
May 14, 2004·The Journal of Biological Chemistry·Vladislav KurtevChristian Seiser
Feb 6, 2007·The Journal of Biological Chemistry·Xuexian O YangChen Dong
Apr 24, 2007·Nature Immunology·Salomé LeibundGut-LandmannCaetano Reis e Sousa
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy J HarrisCharles G Drake
Oct 24, 2007·Molecular Cancer Research : MCR·Milos DokmanovicPaul A Marks
Feb 12, 2008·Nature Medicine·Shean J AujlaJay K Kolls
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takako NagataJay K Kolls
Dec 17, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·James L KreindlerJay K Kolls
Jan 1, 2009·International Journal of Cancer. Journal International Du Cancer·Sudipan KarmakarCarolyn L Smith
Feb 11, 2009·The Journal of Experimental Medicine·Heather R ContiSarah L Gaffen
Apr 22, 2009·Cell Host & Microbe·Frank L van de VeerdonkMihai G Netea
Aug 26, 2009·The Journal of Experimental Medicine·Matthew J RobinsonCaetano Reis e Sousa
Jul 14, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shih-Chin ChengMihai G Netea
Jul 20, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jee H LeeChang H Kim
Aug 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karine LéluJean-Charles Guéry
Apr 27, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lunxu LiuZongbing You
Jul 28, 2012·Journal of Medical Microbiology·Cathy J WatsonMarie Pirotta

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Citations

May 20, 2016·BoneKEy Reports·Patrizia D'Amelio, Francesca Sassi
Dec 6, 2017·Menopause : the Journal of the North American Menopause Society·Caroline M MitchellDavid N Fredricks
Jan 11, 2018·Endocrine-related Cancer·Clovis Boibessot, Paul Toren
Feb 18, 2016·Infection and Immunity·Antonio Cassone, Jack D Sobel
Oct 26, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laure GarnierJean-Charles Guéry
Dec 14, 2018·Current Opinion in HIV and AIDS·Delphine PlanasPetronela Ancuta
Jul 6, 2018·Endocrine-related Cancer·Andrea NicoliniAngelo Carpi
Sep 25, 2019·International Journal of Molecular Sciences·Naoko KandaHidehisa Saeki
Jul 12, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marika OrlovMark M Wurfel
Aug 24, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria AggelakopoulouVily Panoutsakopoulou
Jun 16, 2017·Epigenomics·Thea van den BoschFrank J Dekker
Aug 30, 2018·Disease Models & Mechanisms·Jocelyn M WesselsCharu Kaushic
Oct 12, 2018·Endocrine-related Cancer·Andrea NicoliniAngelo Carpi
Jan 24, 2019·Frontiers in Immunology·Andrea IannelloMarinella Clerico
Oct 23, 2019·Cells·Alessandro MaglioneMarinella Clerico
Dec 31, 2019·Journal of Alzheimer's Disease : JAD·Andrew J SurmakJorge R Barrio
Oct 20, 2018·Frontiers in Immunology·Vaishali R Moulton
Apr 25, 2020·Frontiers in Immunology·Elze Rackaityte, Joanna Halkias
Apr 17, 2019·Experimental & Molecular Medicine·Do-Hyun KimJe-Min Choi
Feb 6, 2020·Seminars in Immunopathology·Laura S PetersonBrice Gaudilliere
Aug 9, 2020·Frontiers in Pharmacology·Alba CalderoneVincenzo Calderone
Oct 4, 2020·Nature Reviews. Rheumatology·Maurizio Cutolo, Rainer H Straub
Jan 14, 2020·Autoimmunity Reviews·Judith MerrheimNadine Dragin
Jun 22, 2021·Frontiers in Molecular Biosciences·Sen LiuQiuyang Zhang
Jun 21, 2021·Journal of Reproductive Immunology·Aera HanSung Ki Lee
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rachel RosenzweigShyam S Bansal
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yaoyao ChangHaitao Xiao

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