Estradiol metabolism: an endocrine biomarker for modulation of human mammary carcinogenesis

Environmental Health Perspectives
N T TelangM P Osborne

Abstract

The natural estrogen 17beta-estradiol (E2) has a profound influence on proliferation and neoplastic transformation of mammary epithelium. The role of cellular metabolism of E2 in mammary carcinogenesis, however, remains to be elucidated. Explant culture and cell culture models developed from noncancerous human mammary tissue were used to examine modulation of E2 metabolism in response to treatment with prototype rodent mammary carcinogens and the ability of the naturally occurring phytochemical indole-3-carbinol (13C) to influence E2 metabolism and regulate aberrant proliferation. In the two models, treatment with the chemical carcinogens 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene altered the metabolism of E2 as determined from the radiometric (tritium release) and gas chromatography-mass spectrometry (GC-MS) assays. This alteration in E2 metabolism was accompanied by aberrant proliferation and abrogation of apoptosis as determined by the extent of replicative DNA synthesis, S-phase fraction and Sub G0 (apoptotic) peak. Exposure of carcinogen-initiated cultures to 13C resulted in induction of C2-hydroxylation of E2 and of apoptosis and downregulation of hyperproliferation. Determination of altered cellular metabolism of ...Continue Reading

References

Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·N T TelangM P Osborne
Mar 1, 1992·Breast Cancer Research and Treatment·J B Adams
Nov 22, 1991·Science·B E HendersonM C Pike
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·C E Sekeris
Nov 1, 1990·Endocrine Reviews·J J Li, S A Li
Jun 6, 1990·Journal of the National Cancer Institute·J J Michnovicz, H L Bradlow
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P M Ingleton, P V Gaitens
Jan 1, 1986·Annals of the New York Academy of Sciences·P Mauvais-JarvisA Gompel
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M R Stampfer, J C Bartley
Sep 1, 1985·Molecular and Cellular Biochemistry·J A Bassuk, S Sorof
Sep 1, 1971·The Biochemical Journal·I A EvansR Mainwaring-Burton
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M R StampferJ C Bartley
Jan 1, 1982·Springer Seminars in Immunopathology·O Stutman
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·S NandiJ Yang
Jan 1, 1993·Journal of Cellular Biochemistry. Supplement·G J KelloffP Greenwald
Oct 1, 1993·Environmental Health Perspectives·D L DavisH Anton-Culver
Jan 19, 1994·Journal of the National Cancer Institute·R K TiwariM P Osborne
Nov 30, 1993·Annals of the New York Academy of Sciences·J RussoI H Russo
Feb 1, 1993·Pharmacology & Therapeutics·C P Martucci, J Fishman
Jan 1, 1993·Epidemiologic Reviews·L Bernstein, R K Ross
Sep 30, 1995·Annals of the New York Academy of Sciences·H L BradlowM P Osborne
Sep 30, 1995·Annals of the New York Academy of Sciences·J FishmanN T Telang
Jan 1, 1996·CA: a Cancer Journal for Clinicians·S L ParkerP A Wingo
Apr 30, 1996·Annals of the New York Academy of Sciences·N T Telang
Aug 19, 1961·Nature·F DEWHURST, G CALCUTT

❮ Previous
Next ❯

Citations

Aug 29, 1998·Environmental Health Perspectives·D L DavisA J Sasco
Feb 23, 2011·International Journal of Women's Health·Nadia ObiJenny Chang-Claude
May 3, 2014·Cancer Letters·Hamed Samavat, Mindy S Kurzer
Jan 1, 1999·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· Leonard I Sweet Dora R Passino-Reader Peter G Meier Geneva M Omann
Feb 17, 2001·Rapid Communications in Mass Spectrometry : RCM·D WilliamsM K Young
Mar 10, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H J YooS P Schantz
May 30, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Edwin K ChanStimson P Schantz
Jun 8, 2017·World Journal of Biological Chemistry·Brigitte Le Magueresse-BattistoniDanielle Naville
Jan 25, 2011·Thyroid : Official Journal of the American Thyroid Association·Shilpi RajoriaRaj K Tiwari
Nov 27, 2002·The American Journal of Clinical Nutrition·Sidika E Kasim-KarakasBill L Lasley
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickUNKNOWN American Association of Clinical Endocrinologists

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis