Estradiol modulates post-ischemic cerebral vascular remodeling and improves long-term functional outcome in a rat model of stroke.

Brain Research
Agnieszka A ArdeltMartin M Pike

Abstract

We previously observed that 17β-estradiol (E2) augments ischemic borderzone vascular density 10 days after focal cerebral ischemia-reperfusion in rats. We now evaluated the effect of E2 on vascular remodeling, lesional characteristics, and motor recovery up to 30 days after injury. Peri-lesional vascular density in tissue sections from rats treated with 0.72 mg E2 pellets was higher compared to 0.18 mg E2 pellets or placebo (P) pellets: vascular density index, 1.9 ± 0.2 (0.72 mg E2) vs. 1.4 ± 0.2 (0.18 mg E2) vs. 1.5 ± 0.4 (P), p=0.01. This was consistent with perfusion magnetic resonance imaging (MRI) measurements of lesional relative cerebral blood flow (rCBF): 1.89 ± 0.32 (0.72 mg E2) vs. 1.32 ± 0.19 (P), p=0.04. Post-ischemic angiogenesis occurred in P-treated as well as E2-treated rats. There was no treatment-related effect on lesional size, but lesional tissue was better preserved in E2-treated rats: cystic component as a % of total lesion, 30 ± 12 (0.72 mg E2) vs. 29 ± 17 (0.18 mg E2) vs. 61 ± 29 (P), p=0.008. Three weeks after right middle cerebral artery territory injury, rats treated with 0.72 mg E2 pellets used the left forelimb more than P-treated or 0.18 mg E2-treated rats: limb use asymmetry score, 0.09 ± 0.43 (0....Continue Reading

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Citations

Mar 29, 2014·Journal of the International Neuropsychological Society : JINS·Ranmalee EramudugollaKaarin J Anstey
Jan 30, 2014·Molecular and Cellular Endocrinology·Limor Raz
Apr 19, 2016·The Journal of Clinical Investigation·David D AufhauserMatthew H Levine
Jun 3, 2014·Frontiers in Neuroendocrinology·Farida Sohrabji
Mar 23, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Anan ShtayaOwen Sparrow

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