Estradiol or fluoxetine alters depressive behavior and tryptophan hydroxylase in rat raphe

Neuroreport
Fu-Zhong YangShen-Xun Shi

Abstract

The effects of 17beta-estradiol and fluoxetine on behavior of ovariectomized rats subjected to the forced swimming test and the expression of tryptophan hydroxylase (TPH) in dorsal and median raphe were investigated, respectively through time sampling technique of behavior scoring and immunohistochemistry. Both estradiol and fluoxetine increased swimming and decreased immobility in the forced swimming test. The forced swimming stress decreased integrated optical density of TPH-positive regions in dorsal and median raphe. Both estradiol and fluoxetine administration prevented integrated optical density of TPH-positive regions from being decreased by forced swimming stress. These observations suggest that both estradiol and fluoxetine have protective bearing on ovariectomized rats enduring forced swimming stress.

References

Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Aug 11, 1964·Biochemical and Biophysical Research Communications·D G Grahame-Smith
Dec 1, 1996·Journal of Neurochemistry·D Mück-SelerM Diksic
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·I M RachmanR S Cohen
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J J Mann
Sep 11, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J A Lieberman, G K Aghajanian
Mar 20, 2002·Molecular Pharmacology·Seong Who KimOnyou Hwang
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erika Estrada-CamarenaCarolina López-Rubalcava
Jun 27, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Evian Gordon
May 12, 2005·Behavioral and Cognitive Neuroscience Reviews·Zenab AminC Neill Epperson
Sep 20, 2006·Pharmacology, Biochemistry, and Behavior·N N DygaloE S Ovchinnikova

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Citations

Dec 17, 2011·Behavioural Brain Research·Jodi L PawluskiDaniël L van den Hove
May 16, 2017·Journal of Exercise Rehabilitation·Mal-Soon ShinBaek-Vin Lim
Jun 30, 2018·Current Neuropharmacology·Olivia Tania Hernández-HernándezGraciela Jiménez-Rubio

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