PMID: 11910618Mar 26, 2002Paper

Estradiol pharmacokinetics after transdermal application of patches to postmenopausal women: matrix versus reservoir patches

Climacteric : the Journal of the International Menopause Society
J Y ReginsterR Lins

Abstract

A new matrix 17 beta-estradiol transdermal patch incorporating lauric acid to improve estradiol skin absorption has been designed for hormone replacement therapy. Estradiol pharmacokinetics obtained with the prototype, its industrial counterpart, a matrix-type, System 50, and a reservoir-type, Estraderm TTS 50, transdermal patch have been compared. Each device delivers 50 micrograms estradiol daily. Twenty postmenopausal women received each of the four formulations for 3 days in a Latin-square design and with a minimum 4-day wash-out period between treatments. Estradiol plasma concentrations were measured by radioimmunoassay at 6, 12, 24, 48 and 72 h after application. The prototype patch and its industrial counterpart showed no significant difference in estradiol delivery, with 72-h systemic exposure to estradiol similar to that of the reservoir patch but greater than that of the reference matrix formulation, with average baseline-corrected concentrations (SEM) of 35 (4), 32 (3), 32 (2) and 19 (1.8) pg/ml, respectively. In addition, they ensured more stable delivery, with coefficients of variation of plasma estradiol concentrations (12-72 h) of 29, 41, 63 and 84%, respectively. All matrix patches demonstrated the same patients...Continue Reading

References

Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·H L Judd
May 1, 1987·American Journal of Obstetrics and Gynecology·R W Lievertz
Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·K A SteingoldH L Judd
Feb 1, 1994·Clinical Pharmacokinetics·B Berner, V A John
Sep 1, 1995·Journal of Clinical Pharmacology·M B O'Connell

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Citations

Nov 19, 2009·Drug Design, Development and Therapy·Nathan W KopperDaniel J Thompson
Apr 1, 2005·Climacteric : the Journal of the International Menopause Society·G Samsioe
Aug 29, 2012·Journal of Pharmaceutical Sciences·Jacquelyn Levin, Howard Maibach
Dec 23, 2008·International Journal of Pharmaceutics·Sara Farahmand, Howard I Maibach
May 26, 2017·Postgraduate Medicine·Keli L BeckJulienne K Kirk
Apr 30, 2010·Expert Opinion on Pharmacotherapy·John E Buster

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