Estradiol regulates MICA expression in human endometrial cells.

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Satarupa BasuCharles L Sentman

Abstract

The human endometrium undergoes cyclical changes regulated by sex hormones. Evidence suggests that sex hormones regulate NK cell recruitment into the uterus in large numbers. NKG2D is an activating receptor expressed on human NK cells, gammadelta and CD8 T cells. NKG2D ligands are known to be sensors of cellular "stress". In this study, we investigated whether sex hormones directly regulate expression of NKG2D ligands in the human uterus. Estradiol increased MICA expression on uterine epithelial cells; regulation was estrogen receptor-dependent. Real-time PCR analysis showed that NKG2D ligands MICA and MICB were expressed in the human endometrium. MICA protein was detected primarily on epithelial cells, and greater expression was observed in immunohistochemical analysis of tissues from patients in the secretory phase of the menstrual cycle. Thus, estrogens regulate expression of MICA. These data suggest hormonal regulation of innate immunity and NKG2D-mediated recognition in other tissues and diseases where estrogen may be involved.

References

Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Jun 1, 1997·American Journal of Reproductive Immunology : AJRI·A KingY W Loke
Sep 30, 1999·Pathology·D H Barkla, P R Gibson
Jul 14, 2001·Nucleic Acids Research·C M Klinge
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Teresa A HendersonHilary O D Critchley
Oct 3, 2003·Nature Reviews. Immunology·David H Raulet
Oct 22, 2003·The Journal of Experimental Medicine·Louise A KoopmanJack L Strominger
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Feb 14, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael T BorchersDavid Cosman
Jan 31, 2007·Annals of the New York Academy of Sciences·Maurizio CutoloRainer H Straub
May 26, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Teddy F MselleCharles L Sentman

❮ Previous
Next ❯

Citations

Sep 8, 2011·Cellular and Molecular Life Sciences : CMLS·Biljana ZafirovaBojan Polić
May 21, 2010·Biology of Reproduction·Leonidas N CarayannopoulosJoan K Riley
Mar 27, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Niramai Sroijak, Mathurose Ponglikitmongkol
Mar 15, 2011·Differentiation; Research in Biological Diversity·Ana KrtolicaSusan J Fisher
Sep 23, 2014·BioMed Research International·Jean Baptiste HaumontePascale Paul
Jun 20, 2019·Frontiers in Immunology·Letizia MarsiliSilvia Casini
Aug 13, 2021·Scientific Reports·Masuma KhatunTerhi T Piltonen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.