PMID: 6980328May 1, 1982Paper

Estradiol regulation of thymic lymphocyte function in the rat: mediation by serum thymic factors

Journal of Steroid Biochemistry
C J GrossmanG A Roselle

Abstract

Estradiol (E2) can depress the function of the thymic lymphocytes. To determine if this response to a gonadal steroid is regulated directly or indirectly, thymic lymphocytes were incubated in vitro for 3 days in the presence of the mitogens concanavalin A (Con A) or phytohaemagglutinin (PHA) + tissue culture media + 20% specific rat serum fractions and pulse labelled with tritiated thymidine. Rat serum fractions were prepared from control, castrate, thymectomized (Tx) and castrate-Tx animals as well as from similar groups of animals treated in vivo for three days with physiological doses of E2. It was found that there was a significant enhancement of thymocyte blastogenesis in cultures incubated with castrate rat serum + Con A or PHA vs. control serum cultures (P less than 0.001). Direct replacement of E2 to castrate sera in vitro at physiological concentrations failed to depress thymocyte blastogenesis to noncastrate levels. Sera prepared from castrate animals treated with E2 at physiological concentrations was successful in depressing the blastogenic response to noncastrate levels. Sera from Tx animals did not enhance Con A induced blastogenesis, but PHA response was significantly increased (P less than 0.01) This effect was ...Continue Reading

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Citations

Feb 1, 1994·Cell and Tissue Research·A G ClarkeM D Kendall
Jul 1, 1983·Journal of Steroid Biochemistry·C J Grossman, G A Roselle
Oct 1, 1983·Journal of Steroid Biochemistry·C J GrossmanG A Roselle
Apr 1, 1984·Journal of Steroid Biochemistry·P MarchettiS Iacobelli
Feb 1, 1990·Journal of Steroid Biochemistry·A H Schuurs, H A Verheul
Jan 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M H MignotJ Schoemaker
Jan 1, 1986·Developmental and Comparative Immunology·K FlurkeyC E Finch
Jan 1, 1988·Developmental and Comparative Immunology·J LecetaA Tejero
Jan 1, 1988·International Journal of Immunopharmacology·C J GrossmanG A Roselle
Feb 1, 1992·International Journal of Immunopharmacology·D Catanzano-TroutaudP A Deschaux
Sep 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·C L MendenhallK Martin
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C J GrossmanC L Mendenhall
Oct 26, 1999·Journal of Reproductive Immunology·K F Windmill, V W Lee
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