Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I.

The Journal of Clinical Endocrinology and Metabolism
J D VeldhuisCacia Soares-Welch

Abstract

Why pulsatile GH secretion declines in estrogen-deficient postmenopausal individuals remains unknown. One possibility is that estrogen not only enhances stimulation by secretagogues but also attenuates negative feedback by systemic IGF-I. SITE: The study took place at an academic medical center. Subjects were healthy postmenopausal women (n=25). The study included randomized assignment to estradiol (n=13) or placebo (n=12) administration for 16 d and randomly ordered administration of 0, 1.0, 1.5, and 2.0 mg/m2 recombinant human IGF-I sc on separate days fasting. Deconvolution analysis of pulsatile and basal GH secretion and approximate entropy (pattern-regularity) analysis were done to quantify feedback effects of IGF-I. Recombinant human IGF-I injections increased mean and peak serum IGF-I concentrations dose dependently (P<0.001) and suppressed mean GH concentrations (P<0.001), pulsatile GH secretion (P=0.001), and approximate entropy (P<0.001). Decreased GH secretion was due to reduced secretory-burst mass (P=0.005) and frequency (P<0.001) but not basal GH release (P=0.52). Estradiol supplementation lowered endogenous, but did not alter infused, IGF-I concentrations while elevating mean GH concentrations (P=0.012) and stimu...Continue Reading

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Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisCyril Y Bowers
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Citations

Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johannes D Veldhuis, Cyril Y Bowers
Jul 11, 2009·Endocrine Reviews·Claes OhlssonJohan Svensson
May 7, 2010·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisPaola Sandroni
May 27, 2011·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisCyril Y Bowers
Oct 12, 2013·European Journal of Endocrinology·Catalina NormanJohannes D Veldhuis
Dec 18, 2015·Physiology·Daniel M Keenan, Johannes D Veldhuis

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