Estradiol treatment and its interaction with the cholinergic system: effects on cognitive function in healthy young women

Hormones and Behavior
Cali F BartholomeuszPradeep J Nathan

Abstract

The steroid hormone estradiol has been shown to modulate cognitive function in both animals and humans, and although the exact mechanisms associated with these effects are unknown, interactions with the cholinergic system have been proposed. We examined the neurocognitive effects of short-term estradiol treatment and its interaction with the cholinergic system using the muscarinic receptor antagonist scopolamine in healthy young women. Thirty-four participants (Mean age+/-SD=22.4+/-4.4) completed baseline cognitive assessment and then received either 100 microg/day transdermal estradiol or transdermal placebo for 31 days. On days 28 and 31 of treatment, further cognitive assessment was performed pre- and 90 min post-scopolamine (0.4 mg) or placebo (saline) injection, under a randomized double-blind placebo-controlled design. Short-term estradiol treatment significantly enhanced spatial working memory with a trend for improvement in long-term verbal learning and memory. Overall, estradiol treatment did not protect against or attenuate the scopolamine-induced impairments in the cognitive domains assessed. Findings suggest that estrogen has minimal effects on cholinergic-mediated cognitive processes following short-term treatment....Continue Reading

Citations

Jul 10, 2010·Menopause : the Journal of the North American Menopause Society·Julie A DumasPaul A Newhouse
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Yolanda R SmithJon-Kar Zubieta
Sep 11, 2014·Developmental Neurobiology·Andrew ChaoLuke Remage-Healey
Sep 10, 2013·Psychoneuroendocrinology·Elizabeth Hampson, Erin E Morley

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